ArticleCPT: pharmacometrics & systems pharmacology2013
Medication-wide association studies.
Article in CPT: pharmacometrics & systems pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A review of validation strategies for computational drug repositioning.Briefings in bioinformatics · 2018Pooled it
- Biological substantiation of antipsychotic-associated pneumonia: Systematic literature review and computational analyses.PloS one · 2017Pooled it
- Machine Learning Estimation of Gestational Age at Delivery Using Linked Mother-Infant Electronic Health Records Across Two Health Systems.medRxiv : the preprint server for health sciences · 2026Article
- Drug combination-wide association studies of cancer.Communications medicine · 2025Article
- Drug use and acute kidney injury: a Drug-Wide Association Study (DWAS) in Denmark and Sweden.Clinical kidney journal · 2025Article
- Prescribed Drug Use and Aneurysmal Subarachnoid Hemorrhage Incidence: A Drug-Wide Association Study.Neurology · 2024Article
- The association between prescription drugs and colorectal cancer prognosis: a nationwide cohort study using a medication-wide association study.BMC cancer · 2023Article
- A medication-wide association study (MWAS) on repurposed drugs for COVID-19 with Pre-pandemic prescription medication exposure and pregnancy outcomes.Scientific reports · 2022Article
- Medication-Wide Association Study Using Electronic Health Record Data of Prescription Medication Exposure and Multifetal Pregnancies: Retrospective Study.JMIR medical informatics · 2022Article
- Mining Electronic Health Records for Drugs Associated With 28-day Mortality in COVID-19: Pharmacopoeia-wide Association Study (PharmWAS).JMIR medical informatics · 2022Article
- Drug prescriptions and dementia incidence: a medication-wide association study of 17000 dementia cases among half a million participants.Journal of epidemiology and community health · 2022Article
- Article
- A semi-automated approach for analyzing collages to inform the design of a family health information management system for Hispanic dementia caregivers.Journal of biomedical informatics · 2019Article
- Systematic assessment of prescribed medications and short-term risk of myocardial infarction - a pharmacopeia-wide association study from Norway and Sweden.Scientific reports · 2019Article
- Signals Among Signals: Prioritizing Nongenetic Associations in Massive Data Sets.American journal of epidemiology · 2019Article
- Bias in pharmacoepidemiologic studies using secondary health care databases: a scoping review.BMC medical research methodology · 2019Article
- Evaluating statistical approaches to leverage large clinical datasets for uncovering therapeutic and adverse medication effects.Bioinformatics (Oxford, England) · 2018Article
- Medication class enrichment analysis: a novel algorithm to analyze multiple pharmacologic exposures simultaneously using electronic health record data.Journal of the American Medical Informatics Association : JAMIA · 2018Article
- Tissue-Specific Analysis of Pharmacological Pathways.CPT: pharmacometrics & systems pharmacology · 2018Article
- Standard-based comprehensive detection of adverse drug reaction signals from nursing statements and laboratory results in electronic health records.Journal of the American Medical Informatics Association : JAMIA · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Undiscovered side effects of drugs can have a profound effect on the health of the nation, and electronic health-care databases offer opportunities to speed up the discovery of these side effects. We applied a "medication-wide association study" approach that combined multivariate analysis with exploratory visualization to study four health outcomes of interest in an administrative claims database of 46 million patients and a clinical database of 11 million patients. The technique had good predictive value, but there was no threshold high enough to eliminate false-positive findings. The visualization not only highlighted the class effects that strengthened the review of specific products but also underscored the challenges in confounding. These findings suggest that observational databases are useful for identifying potential associations that warrant further consideration but are unlikely to provide definitive evidence of causal effects.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.