Evidence map›Paper›PMID 24447690›Full record

Observational studyJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2014

Observational study of regional aortic size referenced to body size: production of a cardiovascular magnetic resonance nomogram.

Anne E Davis, Adam J Lewandowski, Cameron J Holloway, Ntobeko A B Ntusi, Rajarshi Banerjee, Richard Nethononda, Alex Pitcher, Jane M Francis, Saul G Myerson, Paul Leeson and 3 more

Abstract readComparative StudyObservational Study
In one paragraph

Observational study in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Society for Cardiovascular Magnetic Resonance reference values ("normal values") in cardiovascular magnetic resonance: 2025 update.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025
    Guideline
  2. Review
  3. Observational
  4. Ascending aortic aneurysm and dissection risk: focus on aortic height index.Interdisciplinary cardiovascular and thoracic surgery · 2025
    Article
  5. Thoracic aortic aneurysm.Nature reviews. Disease primers · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Development of idealized human aortic models forFrontiers in cardiovascular medicine · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Recent Progress of Chronic Stress in the Development of Atherosclerosis.Oxidative medicine and cellular longevity · 2022
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anne E Davis
Adam J Lewandowski
Cameron J Holloway
Ntobeko A B Ntusi
Rajarshi Banerjee
Richard Nethononda
Alex Pitcher
Jane M Francis
Saul G Myerson
Paul Leeson
Tim Donovan
Stefan Neubauer
Oliver J RiderRadcliffe Department of Medicine, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK. oliver.rider@gmail.com.

Funding

British Heart Foundation FS/08/077/26366British Heart Foundation FS/11/65/28865British Heart Foundation PG/13/58/30397Wellcome Trust 090532
6 · The paper itself

Abstract

backgroundCardiovascular magnetic resonance (CMR) is regarded as the gold standard for clinical assessment of the aorta, but normal dimensions are usually referenced to echocardiographic and computed tomography data and no large CMR normal reference range exists. As a result we aimed to 1) produce a normal CMR reference range of aortic diameters and 2) investigate the relationship between regional aortic size and body surface area (BSA) in a large group of healthy subjects with no vascular risk factors.

methods447 subjects (208 male, aged 19-70 years) without identifiable cardiac risk factors (BMI range 15.7-52.6 kg/m2) underwent CMR at 1.5 T to determine aortic diameter at three levels: the ascending aorta (Ao) and proximal descending aorta (PDA) at the level of the pulmonary artery, and the abdominal aorta (DDA), at a level 12 cm distal to the PDA. In addition, 201 of these subjects had aortic root imaging, allowing for measurements at the level of the aortic valve annulus (AV), aortic sinuses and sinotubular junction (STJ).

resultsNormal diameters (mean ±2 SD) were; AV annulus male(♂) 24.4 ± 5.4, female (♀) 21.0 ± 3.6 mm, aortic sinus♂ 32.4 ± 7.7, ♀27.6 ± 5.8 mm, ST-junction ♂25.0 ± 7.4, ♀21.8 ± 5.4 mm, Ao ♂26.7 ± 7.7, ♀25.5 ± 7.4 mm, PDA ♂20.6 ± 5.6, +18.9 ± 4.0 mm, DDA ♂17.6 ± 5.1, ♀16.4 ± 4.0 mm. Aortic root and thoracic aortic diameters increased at all levels measured with BSA. No gender difference was seen in the degree of dilatation with increasing BSA (p>0.5 for all analyses).

conclusionAcross both genders, increasing body size is characterized by a modest degree of aortic dilatation, even in the absence of traditional cardiovascular risk factors.

Indexed as

Body SizeMagnetic Resonance ImagingNomogramsAdultAgedAge FactorsAortaAortic AneurysmBody Mass IndexBody Surface AreaCross-Sectional StudiesDilatation, PathologicFemaleHumansMaleMiddle Aged

Identifiers

PMID24447690
PMCPMC3899403

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.