Evidence map›Paper›PMID 24447098›Full record

ArticleJournal of the American Chemical Society2014

Protein and enzyme gated supramolecular disassembly.

Jing Guo, Jiaming Zhuang, Feng Wang, Krishna R Raghupathi, S Thayumanavan

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
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  14. Article
  15. Supramolecular copolymers with stimuli-responsive sequence control.Chemical communications (Cambridge, England) · 2015
    Article
  16. Article
  17. Review
  18. Stimuli-responsive nanomaterials for biomedical applications.Journal of the American Chemical Society · 2015
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jing GuoDepartment of Chemistry, University of Massachusetts , Amherst, Massachusetts 01003, United States.
Jiaming Zhuang
Feng Wang
Krishna R Raghupathi
S Thayumanavan

Funding

CHEMISTRY-BIOLOGY INTERFACE PREDOCTORAL TRAINING GRANTST32GM008515 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI THOMPSON, LYNMARIE K. · 1995 to 2020
$4.3M
New Amphiphillic Dendrimers for Encapsulation and ReleaseR01GM065255 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI THAYUMANAVAN, SANKARAN · 2003 to 2019
$4.3M
NIGMS NIH HHS GM065255NIGMS NIH HHS R01 GM065255NIGMS NIH HHS T32 GM008515NIGMS NIH HHS T32 GM08515
6 · The paper itself

Abstract

An amphiphilic nanoassembly was designed to respond to the concurrent presence of a protein and an enzyme. We present herein a system, where in the presence of these two stimuli supramolecular disassembly and molecular release occur. This molecular release arises in the form a fluorescence response that has been shown to be specific. We also show that this system can be modified to respond only if light stimulus is also present in addition to the protein and the enzyme. Demonstration of such supramolecular disassembly principles could have broad implications in a variety of biological applications.

Indexed as

Models, BiologicalBinding SitesCoumarinsEnzymesIndicators and ReagentsMolecular StructureProteinsProtein TransportSubstrate SpecificitycoumarinCoumarinsEnzymesIndicators and ReagentsProteins

Identifiers

PMID24447098
PMCPMC3985736

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.