Trial reportClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2014
Vitamin D-binding protein haplotype is associated with hospitalization for RSV bronchiolitis.
Trial report in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Efficacy of vitamin D supplementation for children with acute bronchiolitis: A randomized controlled trial.World journal of clinical pediatrics · 2026Article
- Association between vitamin D polymorphisms and binding protein and COVID-19 risk and severity in children.Clinical and experimental pediatrics · 2025Article
- The association of rs7041 polymorphism with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome.BMC research notes · 2025Article
- Nutrition, Immunosenescence, and Infectious Disease: An Overview of the Scientific Evidence on Micronutrients and on Modulation of the Gut Microbiota.Advances in nutrition (Bethesda, Md.) · 2022Review
- VDR gene polymorphisms are associated with the increased susceptibility to COVID-19 among iranian population: A case-control study.International journal of immunogenetics · 2022Article
- rs7041 and rs4588 Polymorphisms in Vitamin D Binding Protein Gene (VDBP) and the Risk of Diseases.International journal of molecular sciences · 2022Review
- Vitamin D receptor, vitamin D binding protein and CYP27B1 single nucleotide polymorphisms and susceptibility to viral infections in infants.Scientific reports · 2021Article
- Article
- Controversial Effects of Vitamin D and Related Genes on Viral Infections, Pathogenesis, and Treatment Outcomes.Nutrients · 2020Review
- Association of vitamin D genetic pathway with asthma susceptibility in the Kurdish population.Journal of clinical laboratory analysis · 2020Article
- Host Components Contributing to Respiratory Syncytial Virus Pathogenesis.Frontiers in immunology · 2019Review
- Correlation of vitamin D receptor with bronchial asthma in children.Experimental and therapeutic medicine · 2018Article
- Association of Vitamin D Receptor Polymorphism with Susceptibility to Symptomatic Pertussis.PloS one · 2016Article
- Vitamin D and respiratory tract infections in childhood.BMC infectious diseases · 2015Review
- Genes associated with RSV lower respiratory tract infection and asthma: the application of genetic epidemiological methods to understand causality.Future virology · 2015Article
- Review
- Challenges and opportunities in developing respiratory syncytial virus therapeutics.The Journal of infectious diseases · 2015Article
- Low serum 25-hydroxyvitamin D levels and bronchiolitis severity in Spanish infants.European journal of pediatrics · 2015Article
- Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundBetween 75 000 and 125 000 U.S. infants are hospitalized for respiratory syncytial virus (RSV) bronchiolitis every year. Up to half will be diagnosed with asthma in later childhood. Vitamin D deficiency has been associated with susceptibility to asthma and respiratory infections. Measured vitamin D is largely bound to vitamin D-binding protein (VDBP); VDBP levels are influenced by its gene (GC) haplotype.
objectiveWe assessed the relationship between polymorphisms rs7041 and rs4588, which define haplotypes GC1s, GC1f, and GC2, and RSV bronchiolitis susceptibility and subsequent asthma.
methodsWe retrospectively recruited 198 otherwise healthy children (93% White) hospitalized for severe RSV bronchiolitis in Boston and 333 parents into a follow-up study to assess asthma diagnosis. Data were analysed using family-based genetic association tests. We independently validated our results in 465 White children hospitalized with RSV bronchiolitis and 930 White population controls from the Netherlands.
resultsThe rs7041_C allele (denoting haplotype GC1s) was overtransmitted (P = 0.02, additive model) in the entire Boston cohort, in Whites (P = 0.03), and especially in children subsequently diagnosed with asthma (P = 0.006). The GC1f haplotype was undertransmitted in the asthma subgroups (all races and White, both P < 0.05). The rs7041_C allele was also more frequent in the RSV bronchiolitis group compared with controls (OR 1.12, 95% CI 1.02, 1.4, P = 0.03) in the Netherlands, especially in mechanically ventilated patients (P = 0.009). CONCLUSION AND CLINICAL RELEVANCE: GC1s haplotype carriage may increase the risk of RSV bronchiolitis in infancy and subsequent asthma development. The GC1s haplotype is associated with higher VDBP levels, resulting in less freely available vitamin D. KEY MESSAGES: Vitamin D-binding protein (VDBP) haplotypes influence free vitamin D levels. We report an association between a VDBP haplotype and hospitalization for RSV bronchiolitis in infancy in two independent cohorts.
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