ArticleMicrocirculation (New York, N.Y. : 1994)2014
Exercise training-induced adaptations in mediators of sustained endothelium-dependent coronary artery relaxation in a porcine model of ischemic heart disease.
Article in Microcirculation (New York, N.Y. : 1994), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Exercise training ameliorates myocardial dysfunction through fibronectin-mediated mechanotransduction in a swine model of ischemic heart disease.American journal of physiology. Heart and circulatory physiology · 2026Article
- Exercise decreases the number and modifies the transcriptome of M1 macrophages and CD8American journal of physiology. Cell physiology · 2025Article
- Cardiac rehabilitation in porcine models: Advances in therapeutic strategies for ischemic heart disease.Zoological research · 2025Review
- Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells.Cell communication and signaling : CCS · 2024Article
- Single-nucleus transcriptomics of epicardial adipose tissue from females reveals exercise control of innate and adaptive immune cells.bioRxiv : the preprint server for biology · 2023Article
- Exercise induces superoxide and NOX4 contribution in endothelium-dependent dilation in coronary arterioles from a swine model of chronic myocardial ischemia.Microvascular research · 2023Article
- Cardiovascular Disease and Exercise: From Molecular Mechanisms to Clinical Applications.Journal of clinical medicine · 2022Review
- Protective cardiovascular benefits of exercise training as measured by circulating endothelial cells and high-density lipoprotein in adults.Journal of Taibah University Medical Sciences · 2022Article
- Effects of Exercise on Heart Failure with Preserved Ejection Fraction: An Updated Review of Literature.Journal of cardiovascular development and disease · 2022Review
- Coronary microvascular adaptations distal to epicardial artery stenosis.American journal of physiology. Heart and circulatory physiology · 2021Review
- Enhanced KCl-mediated contractility and CaAmerican journal of physiology. Heart and circulatory physiology · 2020Article
- Roles of sarcoplasmic reticulum CaScientific reports · 2020Article
- Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors.Nature reviews. Cardiology · 2018Review
- Article
- Adaptations of the endothelin system after exercise training in a porcine model of ischemic heart disease.Microcirculation (New York, N.Y. : 1994) · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe aim of this study was to test the hypothesis that exercise training enhances sustained relaxation to persistent endothelium-dependent vasodilator exposure via increased nitric oxide contribution in small coronary arteries of control and ischemic hearts.
methodsYucatan swine were designated to a control group or a group in which an ameroid constrictor was placed around the proximal LCX. Subsequently, pigs from both groups were assigned to exercise (five days/week; 16 weeks) or SED regimens. Coronary arteries (~100-350 μm) were isolated from control pigs and from both nonoccluded and collateral-dependent regions of chronically-occluded hearts.
resultsIn arteries from control pigs, training significantly enhanced relaxation responses to increasing concentrations of bradykinin (10(-10) -10(-7) M) and sustained relaxation to a single bradykinin concentration (30 nM), which were abolished by NOS inhibition. Training also significantly prolonged bradykinin-mediated relaxation in collateral-dependent arteries of occluded pigs, which was associated with more persistent increases in endothelial cellular Ca(2+) levels, and reversed with NOS inhibition. Protein levels for eNOS and p-eNOS-(Ser1179), but not caveolin-1, Hsp90, or Akt, were significantly increased with occlusion, independent of training state.
conclusionsExercise training enhances sustained relaxation to endothelium-dependent agonist stimulation in small arteries of control and ischemic hearts by enhanced nitric oxide contribution and endothelial Ca(2+) responses.
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Registered trials
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