ArticleJournal of the American Chemical Society2014
Remodeling natural products: chemistry and serine hydrolase activity of a rocaglate-derived β-lactone.
Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- A chemoproteomic atlas of the human purine interactome for regioselective ligand discovery.Nature communications · 2026Article
- Protein S-acylation: Pathological mechanisms and novel therapeutic targets for diabetic complications.Chinese herbal medicines · 2026Review
- Activity-Based Acylome Profiling withJournal of the American Chemical Society · 2024Article
- Identification of Rocaglate Acyl Sulfamides as Selective Inhibitors of Glioblastoma Stem Cells.ACS central science · 2024Article
- Exploring the targeting spectrum of rocaglates among eIF4A homologs.RNA (New York, N.Y.) · 2023Article
- A proteome-wide atlas of lysine-reactive chemistry.Nature chemistry · 2021Article
- α/β-Hydrolase Domain (ABHD) Inhibitors as New Potential Therapeutic Options against Lipid-Related Diseases.Journal of medicinal chemistry · 2021Review
- Intercepted Retro-Nazarov Reaction: Syntheses of Amidino-Rocaglate Derivatives and Their Biological Evaluation as eIF4A Inhibitors.Journal of the American Chemical Society · 2019Article
- Chemical Synthesis Enables Structural Reengineering of Aglaroxin C Leading to Inhibition Bias for Hepatitis C Viral Infection.Journal of the American Chemical Society · 2019Article
- A photochemical flow reactor for large scale syntheses of aglain and rocaglate natural product analogues.Bioorganic & medicinal chemistry · 2017Article
- Rh-Catalyzed Conjugate Addition of Aryl and Alkenyl Boronic Acids to α-Methylene-β-lactones: Stereoselective Synthesis of trans-3,4-Disubstituted β-Lactones.Organic letters · 2017Article
- Synthesis of Aza-Rocaglates via ESIPT-Mediated (3+2) Photocycloaddition.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016Article
- Chemical proteomics approaches for identifying the cellular targets of natural products.Natural product reports · 2016Review
- A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway.EBioMedicine · 2015Article
- Facile synthesis of borofragments and their evaluation in activity-based protein profiling.Chemical communications (Cambridge, England) · 2015Article
- Combining cross-metathesis and activity-based protein profiling: new β-lactone motifs for targeting serine hydrolases.Bioorganic & medicinal chemistry letters · 2015Article
- Biomimetic kinetic resolution: highly enantio- and diastereoselective transfer hydrogenation of aglain ketones to access flavagline natural products.Journal of the American Chemical Society · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Flavaglines are a class of natural products with potent insecticidal and anticancer activities. β-Lactones are a privileged structural motif found in both therapeutic agents and chemical probes. Herein, we report the synthesis, unexpected light-driven di-epimerization, and activity-based protein profiling of a novel rocaglate-derived β-lactone. In addition to in vitro inhibition of the serine hydrolases ABHD10 and ACOT1/2, the most potent β-lactone enantiomer was also found to inhibit these enzymes, as well as the serine peptidases CTSA and SCPEP1, in PC3 cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.