ArticleThe Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics2013
Subversive subjects: rule-breaking and deception in clinical trials.
Article in The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Interpretation of Chemistry, Hematology and Coagulation Laboratory Results in Early-Phase Clinical Pharmacology Trials; a Retrospective Analysis Based on the Placebo Arm of Randomized-Controlled Trials.Clinical and translational science · 2026Article
- "Stories like ours continue": A phenomenological exploration of the lived experiences of ex-serial clinical trial volunteers in South India.Dialogues in health · 2025Article
- Mutual Emotional Labor as Method: Building Connections of Care in Qualitative Research.Qualitative report (Online) · 2023Article
- The VolREthics initiative to protect the well-being of healthy volunteers in biomedical research.Nature medicine · 2023Article
- Ethical Criteria for Improved Human Subject Protections in Phase I Healthy Volunteer Trials.Ethics & human research · 2022Article
- The ethical anatomy of payment for research participants.Medicine, health care, and philosophy · 2022Article
- Frequency of concealment, fabrication and falsification of study data by deceptive subjects.Contemporary clinical trials communications · 2021Article
- Informal professionalization of healthy participants in phase I clinical trials in Russia.Clinical trials (London, England) · 2019Article
- Commentary on Zvonareva et al.: Exploring the many meanings of "professional" in research participation.Clinical trials (London, England) · 2019Article
- Appraising Harm in Phase I Trials: Healthy Volunteers' Accounts of Adverse Events.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2019Article
- Are Payments to Human Research Subjects Ethically Suspect?Journal of clinical research best practices · 2019Article
- Healthy Volunteers' Perceptions of the Benefits of Their Participation in Phase I Clinical Trials.Journal of empirical research on human research ethics : JERHRE · 2018Article
- Exceptional Risk: Healthy Volunteers' Perceptions of HIV/AIDS Clinical Trials.Journal of acquired immune deficiency syndromes (1999) · 2018Article
- Deception in clinical trials and its impact on recruitment and adherence of study participants.Contemporary clinical trials · 2018Review
- Detecting Deception in Our Research Participants: Are Your Participants Who You Think They Are?Alcoholism, clinical and experimental research · 2018Review
- Serial Participation and the Ethics of Phase 1 Healthy Volunteer Research.The Journal of medicine and philosophy · 2018Article
- Strategies to exclude subjects who conceal and fabricate information when enrolling in clinical trials.Contemporary clinical trials communications · 2017Article
- Targeting Mediators of Smoking Persistence with Intranasal Insulin.Frontiers in pharmacology · 2017Review
- When Subjects Violate the Research Covenant: Lessons Learned from a Failed Clinical Trial of Fecal Microbiota Transplantation.The American journal of gastroenterology · 2016Article
- Using "clinical trial diaries" to track patterns of participation for serial healthy volunteers in U.S. phase I studies.Journal of empirical research on human research ethics : JERHRE · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Research subjects do not always conform to research requirements. When their personal interests conflict with the demands of participation, some subjects surreptitiously break the rules. These subjects are subversive--they undermine the research endeavor. In rejecting the restrictions research imposes, subversive subjects diminish the value of research results. From one vantage point, subversive subjects engage in unethical behavior. They create risks to themselves and others; they also disregard ethical responsibilities to adhere to research agreements and tell the truth. At the same time, subversive subjects expose ethical problems in the design and conduct of clinical trials. Features of the research environment create fertile ground for subject subversion. Intensified policing and guidance are two common strategies for reducing subject subversion, but collaborative reforms are more consistent with the partnership model of clinical research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.