ArticleAmyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis2014
Pharmaceutical amyloidosis associated with subcutaneous insulin and enfuvirtide administration.
Article in Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 87 citations in OpenAlex.
- FAIM Inhibits Insulin Amyloidogenesis through a Noncanonical Aggregation Pathway.bioRxiv : the preprint server for biology · 2026Article
- AIns (insulin) type amyloidosis in a kidney transplant candidate with a newly identified monoclonal gammopathy.Journal of hematopathology · 2026Article
- Benign fibrous histiocytoma and cutaneous amyloidosis in a patient receiving enfuvirtide injections.JAAD case reports · 2024Article
- Raman Spectroscopic Insights of Phase-Separated Insulin Aggregates.ACS physical chemistry Au · 2024Article
- Clues to the Design of Aggregation-Resistant Insulin from Proline Scanning of Highly Amyloidogenic Peptides Derived from the N-Terminal Segment of the A-Chain.Molecular pharmaceutics · 2024Article
- Fluorimetric Detection of Insulin Misfolding by Probes Derived from Functionalized Fluorene Frameworks.Molecules (Basel, Switzerland) · 2024Article
- Clinical Proteomics for Solid Organ Tissues.Molecular & cellular proteomics : MCP · 2023Article
- Article
- Mesalazine Inhibits Amyloid Formation and Destabilizes Pre-formed Amyloid Fibrils in the Human Insulin.Journal of fluorescence · 2023Article
- Insulin-Derived Cutaneous Amyloidosis: A Possible Complication of Repeated Insulin Injections.Annals of dermatology · 2023Article
- Amyloidogenesis via interfacial shear in a containerless biochemical reactor aboard the International Space Station.NPJ microgravity · 2022Article
- Local Insulin-Derived Amyloidosis Model Confronted with Silymarin: Histological Insights and Gene Expression of MMP, TNF-α, and IL-6.International journal of molecular sciences · 2022Article
- The intriguing dose-dependent effect of selected amphiphilic compounds on insulin amyloid aggregation: Focus on a cholesterol-based detergent, Chobimalt.Frontiers in molecular biosciences · 2022Article
- Subcutaneous amyloidoma models for screening potential anti-fibrillating agents in vivo.STAR protocols · 2021Article
- The Clinical Impact of Proteomics in Amyloid Typing.Mayo Clinic proceedings · 2021Article
- Amyloidoma: a review and case report.Skeletal radiology · 2021Review
- Insulin amyloid polymorphs: implications for iatrogenic cytotoxicity.RSC advances · 2020Article
- Hydroxytyrosol Inhibits Protein Oligomerization and Amyloid Aggregation in Human Insulin.International journal of molecular sciences · 2020Article
- Insulin-derived amyloidosis: The insulin ball, amyloidoma.JAAD case reports · 2020Article
- Silk fibroin safety in the eye: a review that highlights a concern.BMJ open ophthalmology · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Protein and peptide drugs administered subcutaneously, such as insulin can be amyloidogenic and result in localized amyloid deposits at the sites of medication injections. These iatrogenic amyloidoses typically present as a localized subcutaneous nodule or skin reaction at the site of administration, and often pose diagnostic challenges. We have analyzed the amyloid proteome in 52 cases of insulin and enfuvirtide associated amyloidosis using laser microdissection/tandem mass spectrometry. We show that the deposits are composed of the drug, as well as other amyloid precursor proteins such as apolipoproteins A-I, A-IV, E and serum amyloid protein. Mass spectrometry-based amyloid sub-typing allows for accurate amyloid diagnosis with resultant therapeutic and prognostic implications. This insight into the amyloid proteome in drug-induced amyloidosis may help further understand pathogenesis of amyloid fibril formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.