ArticleThe journal of physical chemistry. A2014
Near-infrared excited state dynamics of melanins: the effects of iron content, photo-damage, chemical oxidation, and aggregate size.
Article in The journal of physical chemistry. A, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Article
- Delineating precise surgical resection areas: recent advances in NIR-II fluorescence imaging molecular probes.Frontiers in oncology · 2026Review
- The photoprotection mechanism in the black-brown pigment eumelanin.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Contrast mechanisms in pump-probe microscopy of melanin.Optics express · 2022Article
- The Photophysics and Photochemistry of Melanin- Like Nanomaterials Depend on Morphology and Structure.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Review
- Melanins as Sustainable Resources for Advanced Biotechnological Applications.Global challenges (Hoboken, NJ) · 2021Review
- Phenotypic and Clinical Traits That Correlate with Cognitive Impairment in Caucasian Females.Women's health reports (New Rochelle, N.Y.) · 2021Article
- Probing the heterogeneous structure of eumelanin using ultrafast vibrational fingerprinting.Nature communications · 2020Article
- Transient absorption microscopy: Technological innovations and applications in materials science and life science.The Journal of chemical physics · 2020Article
- Ultrafast spectral hole burning reveals the distinct chromophores in eumelanin and their common photoresponse.Chemical science · 2019Article
- Analysis of Melanin Structure and Biochemical Composition in Conjunctival Melanocytic Lesions Using Pump-Probe Microscopy.Translational vision science & technology · 2019Article
- Unraveling the molecular nature of melanin changes in metastatic cancer.Journal of biomedical optics · 2019Article
- Comparison of pump-probe and hyperspectral imaging in unstained histology sections of pigmented lesions.Biomedical optics express · 2017Article
- Label-Free Imaging of Female Genital Tract Melanocytic Lesions With Pump-Probe Microscopy: A Promising Diagnostic Tool.Journal of lower genital tract disease · 2017Article
- Anomalous evolution of broadband optical absorption reveals dynamic solid state reorganization during eumelanin build-up in thin films.Scientific reports · 2017Article
- Dual-wavelength pump-probe microscopy analysis of melanin composition.Scientific reports · 2016Article
- Invited Review Article: Pump-probe microscopy.The Review of scientific instruments · 2016Review
- Ultrafast transient absorption of eumelanin suspensions: the role of inverse Raman scattering.Biomedical optics express · 2015Article
- Pump-probe imaging of pigmented cutaneous melanoma primary lesions gives insight into metastatic potential.Biomedical optics express · 2015Article
- Comparing in vivo pump-probe and multiphoton fluorescence microscopy of melanoma and pigmented lesions.Journal of biomedical optics · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Ultrafast pump-probe measurements can discriminate the two forms of melanin found in biological tissue (eumelanin and pheomelanin), which may be useful for diagnosing and grading melanoma. However, recent work has shown that bound iron content changes eumelanin's pump-probe response, making it more similar to that of pheomelanin. Here we record the pump-probe response of these melanins at a wider range of wavelengths than previous work and show that with shorter pump wavelengths the response crosses over from being dominated by ground-state bleaching to being dominated by excited-state absorption. The crossover wavelength is different for each type of melanin. In our analysis, we found that the mechanism by which iron modifies eumelanin's pump-probe response cannot be attributed to Raman resonances or differences in melanin aggregation and is more likely caused by iron acting to broaden the unit spectra of individual chromophores in the heterogeneous melanin aggregate. We analyze the dependence on optical intensity, finding that iron-loaded eumelanin undergoes irreversible changes to the pump-probe response after intense laser exposure. Simultaneously acquired fluorescence data suggest that the previously reported "activation" of eumelanin fluorescence may be caused in part by the dissociation of metal ions or the selective degradation of iron-containing melanin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.