ArticleJournal of agricultural and food chemistry2014
Pharmacokinetics of equol, a soy isoflavone metabolite, changes with the form of equol (dietary versus intestinal production) in ovariectomized rats.
Article in Journal of agricultural and food chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Systematic review of the effects of the intestinal microbiota on selected nutrients and non-nutrients.European journal of nutrition · 2018Pooled it
- Exploring microbial dynamics and metabolomic profiling of isoflavone transformation in black and yellow soybean tempe for sustainable functional foods.Food chemistry. Molecular sciences · 2025Article
- In Vivo and In Vitro Mechanisms of Equol Synthesis and Key Influencing Factors: A Critical Review.Nutrients · 2025Review
- Evaluating the relationship between dietary flavonoids intake and constipation incidence in the general US population.BMC gastroenterology · 2024Article
- Safety assessment of (S)-Equol: Subchronic toxicity study in Sprague Dawley Rats.Toxicology reports · 2024Article
- Article
- miR-12135 ameliorates liver fibrosis accompanied with the downregulation of integrin subunit alpha 11.iScience · 2024Article
- Interplay between Phytochemicals and the Colonic Microbiota.Nutrients · 2023Review
- Review
- Review
- Changes in secondary metabolites in soybean (Frontiers in plant science · 2022Article
- The Impact of Estrogen and Estrogen-Like Molecules in Neurogenesis and Neurodegeneration: Beneficial or Harmful?Frontiers in cellular neuroscience · 2021Review
- The drug transporter OAT3 (SLC22A8) and endogenous metabolite communication via the gut-liver-kidney axis.The Journal of biological chemistry · 2017Article
- Article
- Intestinal microbiota: a potential target for the treatment of postmenopausal osteoporosis.Bone research · 2017Review
- Article
- The Chemistry of Gut Microbial Metabolism of Polyphenols.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2016Article
- Soy-based renoprotection.World journal of nephrology · 2016Review
- The impact of equol-producing status in modifying the effect of soya isoflavones on risk factors for CHD: a systematic review of randomised controlled trials.Journal of nutritional science · 2016Review
- Influences of diet and the gut microbiome on epigenetic modulation in cancer and other diseases.Clinical epigenetics · 2015Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Recent findings indicate that soy isoflavones and their metabolites may play a role in mitigating postmenopausal bone loss. Equol, a metabolite of the soy isoflavone daidzein produced by intestinal bacteria, has shown some potential, but only 30-50% of the U.S. population is capable of converting dietary daidzein to equol. There are limited data on the pharmacokinetics of dietary racemic equol and its metabolites. This study was conducted to assess the levels of equol and its conjugates in plasma for a 24 h period resulting from oral administration of dietary daidzein and racemic equol in ovariectomized Sprague-Dawley rats. Plasma samples were analyzed for conjugated and free forms of equol using LC-MS/MS. The maximum plasma concentration (C(max)) and time to reach it (t(max)) for total equol (conjugated and unconjugated) were 8815 ± 2988 nmol/L and 2.17 ± 2.91 h and 3682 ± 2675 nmol/L and 20.67 ± 4.67 h, for dietary equol and daidzein, respectively. Although the majority of equol metabolites present were glucuronide conjugates (≥99%), there were low levels of equol monosulfate present. The changes in equol metabolism, specifically equol conjugates, due to the form of equol may play a role in the potential health benefits of equol.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.