ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2014
Comparison of interval timing behaviour in mice following dorsal or ventral hippocampal lesions with mice having δ-opioid receptor gene deletion.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 79 citations in OpenAlex.
- Reward-reset interval timing drives patch foraging decisions through neural state transitions in dorsomedial striatum.bioRxiv : the preprint server for biology · 2025Article
- Ventral hippocampus mediates inter-trial responding in signaled active avoidance.Behavioural brain research · 2024Article
- Ventral hippocampus mediates inter-trial responding in signaled active avoidance.bioRxiv : the preprint server for biology · 2024Article
- Cerebellar glutamatergic system impacts spontaneous motor recovery by regulating Gria1 expression.NPJ Regenerative medicine · 2022Article
- Ketamine activates adult-born immature granule neurons to rapidly alleviate depression-like behaviors in mice.Nature communications · 2022Article
- Frequency matters: how changes in hippocampal theta frequency can influence temporal coding, anxiety-reduction, and memory.Frontiers in systems neuroscience · 2022Article
- Medial Entorhinal Cortex Excitatory Neurons Are Necessary for Accurate Timing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The dorsal hippocampus is required for the formation of long-term duration memories in rats.The European journal of neuroscience · 2021Article
- Is the scalar property of interval timing preserved after hippocampus lesions?Journal of theoretical biology · 2021Article
- Timing behavior in genetic murine models of neurological and psychiatric diseases.Experimental brain research · 2021Review
- What Behavioral Abilities Emerged at Key Milestones in Human Brain Evolution? 13 Hypotheses on the 600-Million-Year Phylogenetic History of Human Intelligence.Frontiers in psychology · 2021Article
- Five Breakthroughs: A First Approximation of Brain Evolution From Early Bilaterians to Humans.Frontiers in neuroanatomy · 2021Article
- The Peak Interval Procedure in Rodents: A Tool for Studying the Neurobiological Basis of Interval Timing and Its Alterations in Models of Human Disease.Bio-protocol · 2020Article
- Hypothalamus-hippocampus circuitry regulates impulsivity via melanin-concentrating hormone.Nature communications · 2019Article
- Review
- Scalar timing in memory: A temporal map in the hippocampus.Journal of theoretical biology · 2018Article
- A Population-Based Model of the Temporal Memory in the Hippocampus.Frontiers in neuroscience · 2018Article
- Article
- Emotional modulation of interval timing and time perception.Neuroscience and biobehavioral reviews · 2016Review
- Article
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2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mice with cytotoxic lesions of the dorsal hippocampus (DH) underestimated 15 s and 45 s target durations in a bi-peak procedure as evidenced by proportional leftward shifts of the peak functions that emerged during training as a result of decreases in both 'start' and 'stop' times. In contrast, mice with lesions of the ventral hippocampus (VH) displayed rightward shifts that were immediately present and were largely limited to increases in the 'stop' time for the 45 s target duration. Moreover, the effects of the DH lesions were congruent with the scalar property of interval timing in that the 15 s and 45 s functions superimposed when plotted on a relative timescale, whereas the effects of the VH lesions violated the scalar property. Mice with DH lesions also showed enhanced reversal learning in comparison to control and VH lesioned mice. These results are compared with the timing distortions observed in mice lacking δ-opioid receptors (Oprd1(-/-)) which were similar to mice with DH lesions. Taken together, these results suggest a balance between hippocampal-striatal interactions for interval timing and demonstrate possible functional dissociations along the septotemporal axis of the hippocampus in terms of motivation, timed response thresholds and encoding in temporal memory.
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