ArticlePediatrics2014
2010 perinatal GBS prevention guideline and resource utilization.
Article in Pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 58 citations in OpenAlex.
- Molecular characterization of Streptococcus agalactiae strains isolated from pregnant women.Scientific reports · 2025Article
- Safety and effectiveness of the Kaiser Permanente early-onset neonatal sepsis calculator in Qatar.Frontiers in pediatrics · 2025Article
- Evaluating a Modified Use of the Kaiser Permanente Early-onset Sepsis Risk Calculator to Reduce Antibiotic Exposure: a Retrospective Study.BMJ paediatrics open · 2024Article
- Antibiotic Treatment for Well-Appearing Infants Born at ≥35 Weeks' Gestation to Mothers with Chorioamnionitis Before and After Implementation of Neonatal Early-Onset Sepsis Calculator.Journal of patient-centered research and reviews · 2024Article
- Should we give antibiotics to neonates with mild non-progressive symptoms? A comparison of serial clinical observation and the neonatal sepsis risk calculator.Frontiers in pediatrics · 2022Article
- Serotype distribution and incidence of invasive early onset and late onset group B streptococcal disease amongst infants in Singapore.BMC infectious diseases · 2021Article
- Clustered Regularly Interspaced Short Palindromic Repeat Analysis of Clonal Complex 17 Serotype III Group BInternational journal of molecular sciences · 2021Article
- A Prospective Cohort Study of Factors Associated with Empiric Antibiotic De-escalation in Neonates Suspected with Early Onset Sepsis (EOS).Paediatric drugs · 2020Article
- Early-Onset Sepsis Risk Calculator Integration Into an Electronic Health Record in the Nursery.Pediatrics · 2019Article
- Emerging serotype III sequence type 17 group B streptococcus invasive infection in infants: the clinical characteristics and impacts on outcomes.BMC infectious diseases · 2019Article
- Molecular Characteristics and Antimicrobial Resistance of Group B Streptococcus Strains Causing Invasive Disease in Neonates and Adults.Frontiers in microbiology · 2019Article
- Implementation of the sepsis risk score for chorioamnionitis-exposed newborns.Journal of perinatology : official journal of the California Perinatal Association · 2018Article
- What's the harm? Risks and benefits of evolving rule-out sepsis practices.Journal of perinatology : official journal of the California Perinatal Association · 2018Review
- Anti-microbial stewardship: antibiotic use in well-appearing term neonates born to mothers with chorioamnionitis.Journal of perinatology : official journal of the California Perinatal Association · 2017Article
- Management of term infants at increased risk for early-onset bacterial sepsis.Paediatrics & child health · 2017Article
- Evaluation and Management of Women and Newborns With a Maternal Diagnosis of Chorioamnionitis: Summary of a Workshop.Obstetrics and gynecology · 2016Article
- Reappraisal of guidelines for management of neonates with suspected early-onset sepsis.The Journal of pediatrics · 2015Review
- An Institutional Approach to the Management of Asymptomatic Chorioamnionitis-Exposed Infants Born ≥35 Weeks Gestation.Pediatric quality & safetyArticle
- Implementation of a Modified Neonatal Early-onset Sepsis Calculator in Well-baby Nursery: a Quality Improvement Study.Pediatric quality & safetyArticle
- Resource Utilization and Costs Associated with Approaches to Identify Infants with Early-Onset Sepsis.MDM policy & practiceArticle
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesTo quantify differences in early-onset sepsis (EOS) evaluations, evaluation-associated resource utilization, and EOS cases detected, when comparing time periods before and after the implementation of an EOS algorithm based on the Centers for Disease Control and Prevention (CDC) 2010 guidelines for prevention of perinatal Group B Streptococcus (GBS) disease.
methodsRetrospective cohort study of infants born at ≥36 weeks' gestation from 2009 to 2012 in a single tertiary care center. One 12-month period during which EOS evaluations were based on the CDC 2002 guideline was compared with a second 12-month period during which EOS evaluations were based on the CDC 2010 guideline. A cost minimization analysis was performed to determine the EOS evaluation-associated costs and resources during each time period.
resultsDuring the study periods, among well-appearing infants ≥36 weeks' gestation, EOS evaluations for inadequate GBS prophylaxis decreased from 32/1000 to <1/1000 live births; EOS evaluation-associated costs decreased by $6994 per 1000 live births; and EOS evaluation-associated work hours decreased by 29 per 1000 live births. We found no increase in EOS evaluations for other indications, total NICU admissions, frequency of infants evaluated for symptoms before hospital discharge, or incidence of EOS during the 2 study periods.
conclusionsImplementation of an EOS algorithm based on CDC 2010 GBS guidelines resulted in a 25% decrease in EOS evaluations performed among well-appearing infants ≥36 weeks' gestation, attributable to decreased evaluation of infants born in the setting of inadequate indicated GBS prophylaxis. This resulted in significant changes in EOS evaluation-associated resource expenditures.
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