ArticleJapanese journal of radiology2014
Correlation of metabolic tumor volume and 11C-choline uptake with the pathology of prostate cancer: evaluation by use of simultaneously recorded MR and PET images.
Article in Japanese journal of radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Metabolic Volumetric Parameters inContrast media & molecular imaging · 2018Article
- Screening and Detection of Prostate Cancer-Review of Literature and Current Perspective.Indian journal of surgical oncology · 2017Review
- Usefulness of MRI-assisted metabolic volumetric parameters provided by simultaneous (18)F-fluorocholine PET/MRI for primary prostate cancer characterization.European journal of nuclear medicine and molecular imaging · 2015Article
- Novel tools for prostate cancer prognosis, diagnosis, and follow-up.BioMed research international · 2014Review
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeThis study was conducted to assess the relationship between (11)C-choline uptake and pathologic findings obtained by combined use of magnetic resonance (MR) and positron emission tomography (PET) imaging of patients with prostate cancer. MATERIALS AND
methodsWe retrospectively evaluated 69 patients with prostate cancer who underwent (11)C-choline PET-CT and magnetic resonance imaging before radical prostatectomy. Combined MR-PET images were acquired to obtain precise anatomic information. The maximum standardized uptake value (SUVmax) and metabolic tumor volume (MTV) were compared with pathologic findings from resected specimens as the reference standard.
resultsThe mean and standard deviation of tumor SUVmax and MTV were 3.9 ± 1.8 and 12.9 ± 16.4, respectively. Tumors with high MTV (≧8.2) were more likely to be admixed with prostatic intraepithelial neoplasia (PIN) (p < 0.0001) or hyperplasia (p < 0.0001) in the background than those without these findings. Multiple regression analysis also revealed that the presence of hyperplasia (OR; 4.25, 95% CI 1.25-14.4, p = 0.02) and PIN (OR; 9.22, 95% CI 2.60-32.7, p = 0.001) were associated with tumors with high MTV.
conclusionWe have demonstrated, by pathologic evaluation of patients with prostate cancer, that (11)C-choline uptake volume is greater for prostate cancer admixed with PIN and hyperplasia than that without.
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