ArticleScientific reports2014
Pre-seizure state identified by diffuse optical tomography.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Bidirectional Neuronal Control of Epileptiform Activity by Repetitive Transcranial Focused Ultrasound Stimulations.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- Seizure forecasting using machine learning models trained by seizure diaries.Physiological measurement · 2022Article
- Current Review of Optical Neural Interfaces for Clinical Applications.Micromachines · 2021Review
- What Triggers the Interictal Epileptic Spike? A Multimodal Multiscale Analysis of the Dynamic of Synaptic and Non-synaptic Neuronal and Vascular Compartments Using Electrical and Optical Measurements.Frontiers in neurology · 2021Article
- Functional Near-Infrared Spectroscopy and Its Clinical Application in the Field of Neuroscience: Advances and Future Directions.Frontiers in neuroscience · 2020Review
- Spectral entropy indicates electrophysiological and hemodynamic changes in drug-resistant epilepsy - A multimodal MREG study.NeuroImage. Clinical · 2019Article
- Transcranial Recording of Electrophysiological Neural Activity in the Rodent BrainFrontiers in neuroscience · 2019Article
- Seizure Detection and Network Dynamics of Generalized Convulsive Seizures: Towards Rational Designing of Closed-Loop Neuromodulation.Neuroscience journal · 2017Article
- A Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical Stimulation.Scientific reports · 2016Article
- Imaging brain activity during seizures in freely behaving rats using a miniature multi-modal imaging system.Biomedical optics express · 2016Article
- Noninvasive high-speed photoacoustic tomography of cerebral hemodynamics in awake-moving rats.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- Localization of cortical tissue optical changes during seizure activity in vivo with optical coherence tomography.Biomedical optics express · 2015Article
- Towards real-time detection of seizures in awake rats with GPU-accelerated diffuse optical tomography.Journal of neuroscience methods · 2015Article
- Article
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Authors and funding
6 authors.
Funding
Abstract
In epilepsy it has been challenging to detect early changes in brain activity that occurs prior to seizure onset and to map their origin and evolution for possible intervention. Here we demonstrate using a rat model of generalized epilepsy that diffuse optical tomography (DOT) provides a unique functional neuroimaging modality for noninvasively and continuously tracking such brain activities with high spatiotemporal resolution. We detected early hemodynamic responses with heterogeneous patterns, along with intracranial electroencephalogram gamma power changes, several minutes preceding the electroencephalographic seizure onset, supporting the presence of a "pre-seizure" state. We also observed the decoupling between local hemodynamic and neural activities. We found widespread hemodynamic changes evolving from local regions of the bilateral cortex and thalamus to the entire brain, indicating that the onset of generalized seizures may originate locally rather than diffusely. Together, these findings suggest DOT represents a powerful tool for mapping early seizure onset and propagation pathways.
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