Trial reportThe Journal of investigative dermatology2014
UVA irradiation of human skin vasodilates arterial vasculature and lowers blood pressure independently of nitric oxide synthase.
Trial report in The Journal of investigative dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02621866 (A Trial of Daily Ultraviolet Therapy to Reduce Cardiovascular Risk Factors), which is not on this map. Cited by 112 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Trial of Daily Ultraviolet Therapy to Reduce Cardiovascular Risk Factors
Who cites it
112 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Effects of ultraviolet light exposure on blood pressure: a systematic review.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Pooled it
- The effects of sunlight exposure on mortality: a systematic review of epidemiological studies.NIHR open research · 2025Pooled it
- Sunlight exposure practice and its associated factors among infants in Ethiopia, systematic review and meta-analysis.PloS one · 2024Pooled it
- Systematic review on gene-sun exposure interactions in skin cancer.Molecular genetics & genomic medicine · 2023Pooled it
- Green Tea Catechin Association with Ultraviolet Radiation-Induced Erythema: A Systematic Review and Meta-Analysis.Molecules (Basel, Switzerland) · 2021Pooled it
- Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data.PloS one · 2017Pooled it
- A randomised control crossover trial of a theory based intervention to improve sun-safe and healthy behaviours in construction workers: study protocol.BMC public health · 2018Trial
- A randomized clinical trial in vitamin D-deficient adults comparing replenishment with oral vitamin DThe American journal of clinical nutrition · 2017Trial
- Effect of high-dose vitamin D supplementation on cardiometabolic risk factors in subjects with metabolic syndrome: a randomized controlled double-blind clinical trial.Journal of endocrinological investigation · 2016Trial
- Comparing the effects of sun exposure and vitamin D supplementation on vitamin D insufficiency, and immune and cardio-metabolic function: the Sun Exposure and Vitamin D Supplementation (SEDS) Study.BMC public health · 2015Trial
- Beyond total irradiance: a PCA-based filtering framework identifies wavelength-dependent biological signatures of sunlight exposure.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Article
- Acute lack of sunlight exposure is associated with poorer cognitive test performance: evidence from two national cohorts in the United Kingdom.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Article
- Towards a pragmatic message on optimizing sun exposure.Skin health and disease · 2026Article
- Rethinking photosensitization in therapy and sun protection.Chemical science · 2026Review
- Blindspot: how sun exposure guidelines have ignored the health of individuals with skin of color.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Review
- Cutaneous microvascular function is reduced in winter compared with summer in healthy young adults.Physiological reports · 2026Article
- Exploring UVA1-Induced Metabolic Effects in Different In Vitro, Ex Vivo, and In Vivo Systems.Metabolites · 2026Article
- Association between meteorological factors and blood pressure variability in northern Guizhou, China.Frontiers in public health · 2026Article
- Nitric oxide: a gas transmitter in healthy and diseased skin.Medical gas research · 2025Review
- The gut-skin axis: a bi-directional, microbiota-driven relationship with therapeutic potential.Gut microbes · 2025Review
52 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incidence of hypertension and cardiovascular disease (CVD) correlates with latitude and rises in winter. The molecular basis for this remains obscure. As nitric oxide (NO) metabolites are abundant in human skin, we hypothesized that exposure to UVA may mobilize NO bioactivity into the circulation to exert beneficial cardiovascular effects independently of vitamin D. In 24 healthy volunteers, irradiation of the skin with two standard erythemal doses of UVA lowered blood pressure (BP), with concomitant decreases in circulating nitrate and rises in nitrite concentrations. Unexpectedly, acute dietary intervention aimed at modulating systemic nitrate availability had no effect on UV-induced hemodynamic changes, indicating that cardiovascular effects were not mediated via direct utilization of circulating nitrate. UVA irradiation of the forearm caused increased blood flow independently of NO synthase (NOS) activity, suggesting involvement of pre-formed cutaneous NO stores. Confocal fluorescence microscopy studies of human skin pre-labeled with the NO-imaging probe diaminofluorescein 2 diacetate revealed that UVA-induced NO release occurs in a NOS-independent, dose-dependent manner, with the majority of the light-sensitive NO pool in the upper epidermis. Collectively, our data provide mechanistic insights into an important function of the skin in modulating systemic NO bioavailability, which may account for the latitudinal and seasonal variations of BP and CVD.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.