Trial reportJournal of anesthesia2014
Methadone patient-controlled analgesia for postoperative pain: a randomized, controlled, double-blind study.
Trial report in Journal of anesthesia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 38 citations in OpenAlex.
- Intraoperative single-dose methadone significantly affects postoperative morphine consumption in older patients with a hip fracture: the MetaHip randomized controlled trial.Acta orthopaedica · 2026Trial
- [Comparison of postoperative analgesia with methadone versus morphine in cardiac surgery].Brazilian journal of anesthesiology (Elsevier)Trial
- Methadone in the madness: a case series and review of methadone management in hospital settings.Pain management · 2025Review
- What we know and what we don't know about the perioperative use of methadone in children and adolescents.Paediatric anaesthesia · 2023Review
- Effect of deuteration on the single dose pharmacokinetic properties and postoperative analgesic activity of methadone.Drug metabolism and pharmacokinetics · 2022Article
- Low-dose methadone for refractory chronic migraine accompanied by medication-overuse headache: a prospective cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- A Practical Approach to Acute Postoperative Pain Management in Chronic Pain Patients.Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses · 2020Article
- Methadone for Pain Management: A Pharmacotherapeutic Review.CNS drugs · 2020Review
- The Effect of Intraoperative Methadone Compared to Morphine on Postsurgical Pain: A Meta-Analysis of Randomized Controlled Trials.Anesthesiology research and practice · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePostoperative pain is an important health-care issue. Patient-controlled analgesia (PCA) is considered the gold standard for systemic postoperative pain treatment. Methadone PCA is used for patients with chronic pain and those in the palliative care setting. However, its efficacy as a first-line drug for acute postoperative pain is unknown. This study evaluated the use of postoperative methadone PCA after total hip arthroplasty (THA) compared with morphine PCA.
methodsThis was a randomized, double-blind, controlled, parallel-group study. Patients were randomized into two groups: group methadone--methadone PCA, and group morphine--morphine PCA, for postoperative analgesia. Drugs were delivered through PCA pumps throughout the first 24 h after surgery (T1:6, T2:12, T3:18, T4:24 h).
resultsOpioid consumption in 24 h was significantly lower for group methadone than for group morphine. Group methadone patients experienced significantly less pain than group morphine at rest. Pain after movement was significantly lower in group methadone at T1 and T3 and marginally lower at T2 and T4. Adverse events more frequently reported were sleepiness, nausea, and vomiting, but no statistical difference between groups was found.
conclusionThis study demonstrated that methadone PCA prompted less opioid consumption and lower pain scores at rest and at motion in comparison with morphine PCA as postoperative analgesia after THA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.