ArticleScientific reports2014
Actomyosin contractility rotates the cell nucleus.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Nuclear Mechanics and Nuclear Mechanotransduction in Cancer Cell Migration and Invasion.Biomolecules · 2026Review
- Epithelial cell chirality emerges through the dynamic concentric pattern of actomyosin cytoskeleton.eLife · 2025Article
- Topology controls flow patterns in active double emulsions.Nature communications · 2025Article
- Yielding behaviour of active particles in bulk and in confinement.Nature physics · 2025Article
- Chirality and odd mechanics in active columnar phases.PNAS nexus · 2024Article
- Article
- A cytoskeletal vortex drives phage nucleus rotation during jumbo phage replication in E. coli.Cell reports · 2022Article
- Cell chirality regulates coherent angular motion on small circular substrates.Biophysical journal · 2022Article
- The 3D Genome: From Structure to Function.International journal of molecular sciences · 2021Review
- Review
- Mechanical stress triggers nuclear remodeling and the formation of transmembrane actin nuclear lines with associated nuclear pore complexes.Molecular biology of the cell · 2020Article
- Centrosome-nuclear axis repositioning drives the assembly of a bipolar spindle scaffold to ensure mitotic fidelity.Molecular biology of the cell · 2020Article
- Tunable corrugated patterns in an active nematic sheet.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Extracellular Matrix Geometry and Initial Adhesive Position Determine Stress Fiber Network Organization during Cell Spreading.Cell reports · 2019Article
- Spontaneous rotation can stabilise ordered chiral active fluids.Nature communications · 2019Article
- Nuclear positioning in migrating fibroblasts.Seminars in cell & developmental biology · 2018Review
- A nonequilibrium force can stabilize 2D active nematics.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Regulation of genome organization and gene expression by nuclear mechanotransduction.Nature reviews. Molecular cell biology · 2017Review
- Nuclear Positioning and Its Translational Dynamics Are Regulated by Cell Geometry.Biophysical journal · 2017Article
- Bridging the Gap: From 2D Cell Culture to 3D Microengineered Extracellular Matrices.Advanced healthcare materials · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cell nucleus functions amidst active cytoskeletal filaments, but its response to their contractile stresses is largely unexplored. We study the dynamics of the nuclei of single fibroblasts, with cell migration suppressed by plating onto micro-fabricated patterns. We find the nucleus undergoes noisy but coherent rotational motion. We account for this observation through a hydrodynamic approach, treating the nucleus as a highly viscous inclusion residing in a less viscous fluid of orientable filaments endowed with active stresses. Lowering actin contractility selectively by introducing blebbistatin at low concentrations drastically reduced the speed and coherence of the angular motion of the nucleus. Time-lapse imaging of actin revealed a correlated hydrodynamic flow around the nucleus, with profile and magnitude consistent with the results of our theoretical approach. Coherent intracellular flows and consequent nuclear rotation thus appear to be an intrinsic property of cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.