ArticleScientific reports2014
Effects of antioxidants on the quality and genomic stability of induced pluripotent stem cells.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Targeting myostatin using quercetin as a media supplement to improve myogenesis for cultured meat production: AnCurrent research in food science · 2024Article
- Neuromodulation of BAG co-chaperones by HIV-1 viral proteins and HCell death discovery · 2021Article
- Genomic integrity of human induced pluripotent stem cells: Reprogramming, differentiation and applications.World journal of stem cells · 2019Review
- The Role of N-Acetylcysteine Supplementation on the Oxidative Stress Levels, Genotoxicity and Lineage Commitment Potential ofSultan Qaboos University medical journal · 2018Article
- Pharmacological Regulation of Oxidative Stress in Stem Cells.Oxidative medicine and cellular longevity · 2018Review
- Chondrocytes differentiated from human induced pluripotent stem cells: Response to ionizing radiation.PloS one · 2018Article
- Genotoxic Effects of Culture Media on Human Pluripotent Stem Cells.Scientific reports · 2017Article
- Effects of Antioxidant Supplements on the Survival and Differentiation of Stem Cells.Oxidative medicine and cellular longevity · 2017Review
- Energy Metabolism Plays a Critical Role in Stem Cell Maintenance and Differentiation.International journal of molecular sciences · 2016Review
- Estrogen deficiency heterogeneously affects tissue specific stem cells in mice.Scientific reports · 2015Article
- Inducing pluripotency in vitro: recent advances and highlights in induced pluripotent stem cells generation and pluripotency reprogramming.Cell proliferation · 2015Review
- Pluripotent stem cell energy metabolism: an update.The EMBO journal · 2015Review
- Metabolic regulation of redox status in stem cells.Antioxidants & redox signaling · 2014Review
- On the Use of Solid Lipid Nanoparticles for Delivering Lavender Hydroalcoholic Extract as an Antioxidant to NMRI Mice Spermatozoa During Handling, Cryopreservation, and Thawing.Reproductive medicine and biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effects of antioxidants on the quality and genomic stability of induced pluripotent stem (iPS) cells were investigated with two human iPS cell lines (201B7 and 253G1). Cells used in this study were expanded from a single colony of each cell line with the addition of proprietary antioxidant supplement or homemade antioxidant cocktail in medium, and maintained in parallel for 2 months. The cells grew well in all culture conditions and kept "stemness". Although antioxidants modestly decreased the levels of intracellular reactive oxygen species, there were no differences in the expression of 53BP1 and pATM, two critical molecules related with DNA damage and repair, under various culture conditions. CGH analysis showed that the events of genetic aberrations were decreased only in the 253G1 iPS cells with the addition of homemade antioxidant cocktail. Long-term culture will be necessary to confirm whether low dose antioxidants improve the quality and genomic stability of iPS cells.
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Registered trials
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