ArticleMarine drugs2014
Oxylipin diversity in the diatom family Leptocylindraceae reveals DHA derivatives in marine diatoms.
Article in Marine drugs, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Cratenin, a Rare Oxylipin Marking Kleptopredation in Aeolid Nudibranchs.Journal of natural products · 2026Article
- Diatoms (Bacillariophyta) of the Salish Sea, Northeast Pacific: annotated checklist and new species reports.Biodiversity data journal · 2026Article
- Microalgae as a New Source of Oxylipins: A Comprehensive LC-MS-Based Analysis Using Conventional and Green Extraction Methods.Journal of agricultural and food chemistry · 2024Article
- Viral Infection Leads to a Unique Suite of Allelopathic Chemical Signals in Three Diatom Host-Virus Pairs.Marine drugs · 2024Article
- Structural and Functional Characterization of Lipoxygenases from Diatoms by Bioinformatics and Modelling Studies.Biomolecules · 2024Article
- 14,17,18-Trihydroxy-Eicosatetraenoic Acid: A Novel Pro-Resolving Lipid Mediator from Marine Microalgae.ACS pharmacology & translational science · 2021Article
- Fatty Acids Derivatives From Eukaryotic Microalgae, Pathways and Potential Applications.Frontiers in microbiology · 2021Review
- Article
- Multiple Roles of Diatom-Derived Oxylipins within Marine Environments and Their Potential Biotechnological Applications.Marine drugs · 2020Review
- Genome-enabled phylogenetic and functional reconstruction of an araphid pennate diatom Plagiostriata sp. CCMP470, previously assigned as a radial centric diatom, and its bacterial commensal.Scientific reports · 2020Article
- Comparative Transcriptomic Analysis Uncovers Genes Responsible for the DHA Enhancement in the MutantMicroorganisms · 2020Article
- Combined Effects of Diatom-Derived Oxylipins on the Sea UrchinInternational journal of molecular sciences · 2020Article
- Lipoxygenase Pathways in Diatoms: Occurrence and Correlation with Grazer Toxicity in Four Benthic Species.Marine drugs · 2020Article
- Density-dependent oxylipin production in natural diatom communities: possible implications for plankton dynamics.The ISME journal · 2020Article
- Molecular and Morphological Toxicity of Diatom-Derived Hydroxyacid Mixtures to Sea UrchinMarine drugs · 2019Article
- Article
- Field sampling marine plankton for biodiscovery.Scientific reports · 2017Article
- Diatom flagellar genes and their expression during sexual reproduction in Leptocylindrus danicus.BMC genomics · 2017Article
- First Morphological and Molecular Evidence of the Negative Impact of Diatom-Derived Hydroxyacids on the Sea Urchin Paracentrotus lividus.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- Low-Molecular-Weight Metabolites from Diatoms: Structures, Biological Roles and Biosynthesis.Marine drugs · 2015Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marine planktonic organisms, such as diatoms, are prospective sources of novel bioactive metabolites. Oxygenated derivatives of fatty acids, generally referred to as oxylipins, in diatoms comprise a highly diverse and complex family of secondary metabolites. These molecules have recently been implicated in several biological processes including intra- and inter-cellular signaling as well as in defense against biotic stressors and grazers. Here, we analyze the production and diversity of C20 and C22 non-volatile oxylipins in five species of the family Leptocylindraceae, which constitute a basal clade in the diatom phylogeny. We report the presence of species-specific lipoxygenase activity and oxylipin patterns, providing the first demonstration of enzymatic production of docosahexaenoic acid derivatives in marine diatoms. The differences observed in lipoxygenase pathways among the species investigated broadly reflected the relationships observed with phylogenetic markers, thus providing functional support to the taxonomic diversity of the individual species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.