ArticleMarine drugs2014
Haloperoxidase mediated quorum quenching by Nitzschia cf pellucida: study of the metabolization of N-acyl homoserine lactones by a benthic diatom.
Article in Marine drugs, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 38 citations in OpenAlex.
- Short Synthesis of Structurally DiverseInternational journal of molecular sciences · 2025Article
- A review of quorum-sensing and its role in mediating interkingdom interactions in the ocean.Communications biology · 2025Review
- Synthesis of Mixed Phosphonate Esters and Amino Acid-Based Phosphonamidates, and Their Screening as Herbicides.International journal of molecular sciences · 2024Article
- Diatom-Bacteria Interactions in the Marine Environment: Complexity, Heterogeneity, and Potential for Biotechnological Applications.Microorganisms · 2023Review
- How Do Quorum-Sensing Signals Mediate Algae-Bacteria Interactions?Microorganisms · 2021Review
- Distinctive Growth and Transcriptional Changes of the DiatomFrontiers in microbiology · 2020Article
- Total synthesis of diazaquinomycins H and J using double Knorr cyclization in the presence of triisopropylsilane.RSC advances · 2019Article
- Quorum sensing is a language of chemical signals and plays an ecological role in algal-bacterial interactions.Critical reviews in plant sciences · 2016Article
- Low-Molecular-Weight Metabolites from Diatoms: Structures, Biological Roles and Biosynthesis.Marine drugs · 2015Review
- Quorum quenching agents: resources for antivirulence therapy.Marine drugs · 2014Review
- Bacteria in Ostreococcus tauri cultures - friends, foes or hitchhikers?Frontiers in microbiology · 2014Article
- Synthesis and biological evaluation of novel N-α-haloacylated homoserine lactones as quorum sensing modulators.Beilstein journal of organic chemistry · 2014Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diatoms are known to produce a variety of halogenated compounds, which were recently shown to have a role in allelopathic interactions between competing species. The production of these compounds is linked to haloperoxidase activity. This research, has shown that this system may also be involved in diatom-bacteria interactions via the H2O2 dependent inactivation of a type of quorum sensing (QS) molecule, i.e., N-β-ketoacylated homoserine lactones (AHLs), by a natural haloperoxidase system from the benthic diatom Nitzschia cf pellucida. The AHL degradation pathway towards corresponding halogenated derivatives was elucidated via HPLC-MS analysis and the synthesis of a broad series of novel halogenated AHL analogues as reference compounds. Furthermore, their biological activity as quorum sensing modulators was directly compared and evaluated against a series of naturally occurring β-keto-AHLs. It has been demonstrated that the loss of the QS activity results from the final cleavage of the halogenated N-acyl chain of the signal molecules.
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