Evidence map›Paper›PMID 24445073›Full record

ArticleBehavioural brain research2014

Effects of kappa opioid receptors on conditioned place aversion and social interaction in males and females.

Cindee F Robles, Marissa Z McMackin, Katharine L Campi, Ian E Doig, Elizabeth Y Takahashi, Michael C Pride, Brian C Trainor

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioural brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 67 citations in OpenAlex.

  1. BLA kappa opioid receptor inputs to the BNST mediate social stress-induced increases in alcohol drinking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Triazole 187 is a biased KOR agonist that suppresses itch without sedation and induces anxiolytic-like behaviors in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
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  7. BLAbioRxiv : the preprint server for biology · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Systemic kappa opioid receptor antagonism accelerates reinforcement learning via augmentation of novelty processing in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Mean Girls: Social Stress Models for Female Rodents.Current topics in behavioral neurosciences · 2022
    Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Cindee F RoblesDepartment of Psychology, University of California, Davis, CA 95616, USA; Department of Psychology, Michigan State University, East Lansing, MI, ZIP, USA.
Marissa Z McMackinMolecular, Cellular, and Integrative Physiology Graduate Group, University of California, Davis, CA 95616, USA.
Katharine L CampiDepartment of Psychology, University of California, Davis, CA 95616, USA; Center for Neuroscience, University of California, Davis, CA 95616, USA.
Ian E DoigDepartment of Psychology, University of California, Davis, CA 95616, USA.
Elizabeth Y TakahashiDepartment of Psychology, University of California, Davis, CA 95616, USA.
Michael C PrideDepartment of Psychology, University of California, Davis, CA 95616, USA.
Brian C TrainorDepartment of Psychology, University of California, Davis, CA 95616, USA; Molecular, Cellular, and Integrative Physiology Graduate Group, University of California, Davis, CA 95616, USA; Center for Neuroscience, University of California, Davis, CA 95616, USA. Electronic address: bctrainor@ucdavis.edu.
University of California, Davis · US

Funding

Sex differences in mesolimbic dopamine responses to social stressR01MH097714 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TRAINOR, BRIAN C · 2013 to 2013
$373k
NIMH NIH HHS R01 MH097714
6 · The paper itself

Abstract

The effects of kappa opioid receptors (KOR) on motivated behavior are well established based on studies in male rodents, but relatively little is known about the effects of KOR in females. We examined the effects of KOR activation on conditioned place aversion and social interaction in the California mouse (Peromyscus californicus). Important differences were observed in long-term (place aversion) and short-term (social interaction) effects. Females but not males treated with a 2.5 mg/kg dose of U50,488 formed a place aversion, whereas males but not females formed a place aversion at the 10 mg/kg dose. In contrast the short term effects of different doses of U50,488 on social interaction behavior were similar in males and females. Acute injection with 10 mg/kg of U50,488 (but not lower doses) reduced social interaction behavior in both males and females. The effects of U50,488 on phosphorylated extracellular signal regulated kinase (pERK) and p38 MAP kinase were cell type and region specific. Higher doses of U50,488 increased the number of pERK neurons in the ventrolateral bed nucleus of the stria terminals in males but not females, a nucleus implicated in male aggressive behavior. In contrast, both males and females treated with U50,488 had more activated p38 cells in the nucleus accumbens shell. Unexpectedly, cells expressing activated p38 co-expressed Iba-1, a widely used microglia marker. In summary we found strong sex differences in the effects of U50,488 on place aversion whereas the acute effects on U50,488 induced similar behavioral effects in males and females.

Indexed as

Social Behavior3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-IsomerAnimalsAvoidance LearningConditioning, PsychologicalFemaleMaleMiceMitogen-Activated Protein Kinase 3Nucleus Accumbensp38 Mitogen-Activated Protein KinasesPhosphorylationReceptors, Opioid, kappaSex Factors3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-IsomerMitogen-Activated Protein Kinase 3p38 Mitogen-Activated Protein KinasesReceptors, Opioid, kappaAversionKappa opioid receptorSex DifferenceSocial behavior

Identifiers

PMID24445073
PMCPMC4073310
OpenAlexW2064450732

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.