Evidence map›Paper›PMID 24445065›Full record

ArticleOsteoarthritis and cartilage2014

Age-related differences in sagittal-plane knee function at heel-strike of walking are increased in osteoarthritic patients.

J Favre, J C Erhart-Hledik, T P Andriacchi

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
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  5. Therapeutic Footwear for Medial Knee Osteoarthritis: Individualizing Midsole Stiffness Enhances Intended Kinetic Changes.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
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  8. Knee Flexion Excursion Mediates the Association Between Quadriceps Stiffness and Knee Loads During the Mid-Stance Phase of Gait.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
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  9. Article
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  11. Assessment of varus thrust using inertial measurement units.Clinical biomechanics (Bristol, Avon) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

J FavreDepartment of Mechanical Engineering, Stanford University, Stanford, CA, USA. Electronic address: jfavre@stanford.edu.
J C Erhart-HledikDepartment of Mechanical Engineering, Stanford University, Stanford, CA, USA; Palo Alto VA, Palo Alto, CA, USA. Electronic address: jerhart@stanford.edu.
T P AndriacchiDepartment of Mechanical Engineering, Stanford University, Stanford, CA, USA; Palo Alto VA, Palo Alto, CA, USA; Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA. Electronic address: tandriac@stanford.edu.
Stanford University · US

Funding

Anterior Cruciate Ligament Reconstruction and the Initiation of OsteoarthritisR01AR039421 · NIAMS · STANFORD UNIVERSITY · PI ANDRIACCHI, THOMAS P · 1988 to 2013
$3.3M
NIAMS NIH HHS 5R01-AR039421NIAMS NIH HHS R01 AR039421
6 · The paper itself

Abstract

objectiveTo compare age-related patterns of gait with patterns associated with knee osteoarthritis (OA), the following hypotheses were tested: (H1) The sagittal-plane knee function during walking is different between younger and older asymptomatic subjects; (H2) The age-related differences in H1 are increased in patients with knee OA.

designWalking trials were collected for 110 participants (1.70 ± 0.09 m, 80 ± 14 kg). There were 29 younger asymptomatic subjects (29 ± 4 years) and 81 older participants (59 ± 9 years), that included 27 asymptomatic subjects and 28 and 26 patients with moderate and severe medial knee OA. Discrete variables characterizing sagittal-plane knee function were compared among the four groups using ANOVAs.

resultsDuring the heel-strike portion of the gait cycle at preferred walking speed, the knee was less extended and the shank less inclined in the three older groups compared to the younger asymptomatic group. There were similar differences between the severe OA group and the older asymptomatic and moderate OA groups. Both OA groups also had the femur less posterior relative to the tibia and smaller extension moment than the younger group. During terminal stance, the severe OA group had the knee less extended and smaller knee extension moment than the younger asymptomatic and older moderate OA groups.

conclusionsThe differences in knee function, particularly those during heel-strike which were associated with both age and disease severity, could form a basis for looking at mechanical risk factors for initiation and progression of knee OA on a prospective basis.

Indexed as

AdultAgedAge FactorsBiomechanical PhenomenaFemaleGaitHumansKnee JointMaleMiddle AgedOsteoarthritis, KneeWalkingAgingGait analysisKinematicsKineticsOsteoarthritis

Identifiers

PMID24445065
PMCPMC4211113
OpenAlexW2044782172

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.