ArticleThe Journal of nutritional biochemistry2014
The regulation of hepatic Pon1 by a maternal high-fat diet is gender specific and may occur through promoter histone modifications in neonatal rats.
Article in The Journal of nutritional biochemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 68 citations in OpenAlex.
- High-fat diet in early life triggers both reversible and persistent epigenetic changes in the medaka fish (Oryzias latipes).BMC genomics · 2023Article
- Dietary trends and the decline in male reproductive health.Hormones (Athens, Greece) · 2023Review
- Exposure to maternal fuels during pregnancy and offspring hepatic fat in early childhood: The healthy start study.Pediatric obesity · 2022Article
- The Relationship between Cancer and Paraoxonase 1.Antioxidants (Basel, Switzerland) · 2022Review
- Gestational exposure to high fat diets and bisphenol A alters metabolic outcomes in dams and offspring, but produces hepatic steatosis only in dams.Chemosphere · 2022Article
- Integrated Analysis of Liver Transcriptome, miRNA, and Proteome of Chinese Indigenous Breed Ningxiang Pig in Three Developmental Stages Uncovers Significant miRNA-mRNA-Protein Networks in Lipid Metabolism.Frontiers in genetics · 2021Article
- Maternal Obesity, Maternal Overnutrition and Fetal Programming: Effects of Epigenetic Mechanisms on the Development of Metabolic Disorders.Current genomics · 2019Review
- Histone Modifications as an Intersection Between Diet and Longevity.Frontiers in genetics · 2019Review
- Maternal obesity impairs skeletal development in adult offspringThe Journal of endocrinology · 2018Article
- Epigenetic Regulation of Centromere Chromatin Stability by Dietary and Environmental Factors.Advances in nutrition (Bethesda, Md.) · 2017Review
- Connecting the Dots Between Fatty Acids, Mitochondrial Function, and DNA Methylation in Atherosclerosis.Current atherosclerosis reports · 2017Review
- Persistent DNA methylation changes associated with prenatal mercury exposure and cognitive performance during childhood.Scientific reports · 2017Article
- Traffic-derived particulate matter exposure and histone H3 modification: A repeated measures study.Environmental research · 2017Article
- Developmental origins of NAFLD: a womb with a clue.Nature reviews. Gastroenterology & hepatology · 2017Review
- Experimental Models of Maternal Obesity and Neuroendocrine Programming of Metabolic Disorders in Offspring.Frontiers in endocrinology · 2017Review
- Epigenetic Matters: The Link between Early Nutrition, Microbiome, and Long-term Health Development.Frontiers in pediatrics · 2017Review
- Transgenerational effects of maternal diet on metabolic and reproductive ageing.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Review
- Developmental bisphenol A (BPA) exposure leads to sex-specific modification of hepatic gene expression and epigenome at birth that may exacerbate high-fat diet-induced hepatic steatosis.Toxicology and applied pharmacology · 2015Article
- Developmental Programming of Nonalcoholic Fatty Liver Disease: The Effect of Early Life Nutrition on Susceptibility and Disease Severity in Later Life.BioMed research international · 2015Review
- Epigenetics and nutritional environmental signals.Integrative and comparative biology · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The antioxidant (AOX) defense system is critical for combating whole-body oxidative stress, and the present study aimed to determine the consequences of a maternal high-fat (HF) diet on neonatal hepatic lipid accumulation, oxidative stress, the expression of AOX genes, as well as epigenetic histone modifications within Pon1, an AOX enzyme. Hepatic thiobarbituric acid reactive substances were significantly increased and nonesterified fatty acids decreased in offspring of HF-fed dams, while triglycerides increased in male but not female HF offspring when compared to controls (C). Pon1, Pon2, Pon3 and Sod2 were significantly increased in offspring of HF-fed dams when compared to C. However, the increase in Pon1 and Pon3 was only significant in male but not female offspring. When compared to C, the hepatic Pon1 promoter of male and female HF offspring had significantly more acetylated histone H4 as well as dimethylated histone H3 at lysine residue 4, which are both involved in transcriptional activation. Trimethylation of histone H3 at lysine residue 9, which is involved in transcriptional repression, was only associated with genes in females. Results from the present study reveal that a maternal HF diet affects hepatic metabolism in the neonate in a gender-specific manner, and these differences, in association with epigenetic modification of histones, may contribute to the known gender differences in oxidative balance.
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