Evidence map›Paper›PMID 24444862›Full record

Trial reportSchizophrenia bulletin2015

Neuroplasticity-based auditory training via laptop computer improves cognition in young individuals with recent onset schizophrenia.

Melissa Fisher, Rachel Loewy, Cameron Carter, Ashley Lee, J Daniel Ragland, Tara Niendam, Danielle Schlosser, Lien Pham, Tara Miskovich, Sophia Vinogradov

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Schizophrenia bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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  4. European Psychiatric Association guidance on assessment of cognitive impairment in schizophrenia.European psychiatry : the journal of the Association of European Psychiatrists · 2022
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  7. Video games for people with schizophrenia.The Cochrane database of systematic reviews · 2021
    Pooled it
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  9. Psychological interventions for psychosis in adolescents.The Cochrane database of systematic reviews · 2020
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Melissa FisherDepartment of Psychiatry, University of California, San Francisco, CA; Department of Psychiatry, San Francisco Department of Veterans Affairs Medical Center, San Francisco, CA;
Rachel LoewyDepartment of Psychiatry, University of California, San Francisco, CA;
Cameron CarterDepartment of Psychiatry, University of California, Davis, CA.
Ashley LeeDepartment of Psychiatry, University of California, San Francisco, CA;
J Daniel RaglandDepartment of Psychiatry, University of California, Davis, CA.
Tara NiendamDepartment of Psychiatry, University of California, Davis, CA.
Danielle SchlosserDepartment of Psychiatry, University of California, San Francisco, CA;
Lien PhamDepartment of Psychiatry, University of California, Davis, CA.
Tara MiskovichDepartment of Psychiatry, University of California, Davis, CA.
Sophia VinogradovDepartment of Psychiatry, University of California, San Francisco, CA; Department of Psychiatry, San Francisco Department of Veterans Affairs Medical Center, San Francisco, CA; Sophia.vinogradov@ucsf.edu.

Funding

Neuroscience-Guided Cognitive Remediation in Adolescents at Risk for PsychosisR01MH081051 · NIMH · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI VINOGRADOV, SOPHIA · 2008 to 2012
$2.4M
Neurobiological Mechanisms Underlying the Symptoms and Course of SchizophreniaT32MH089920 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FORD, JUDITH M · 2010 to 2014
$1.3M
PRIME to Action: Enhancing Motivation in Recent Onset SchizophreniaK23MH097795 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SCHLOSSER, DANIELLE A. · 2013 to 2016
$704k
NIMH NIH HHS 5R01MH081051NIMH NIH HHS K23 MH097795NIMH NIH HHS T32 MH089920
6 · The paper itself

Abstract

objectiveCognitive deficits that characterize schizophrenia are present in the prodrome, worsen with illness onset, and predict functional outcome. Cognitive dysfunction is thus a critical target for early intervention in young individuals with recent onset schizophrenia.

methodThis 2-site double-blind randomized controlled trial investigated cognitive training of auditory processing/verbal learning in 86 subjects with recent onset schizophrenia (mean age of 21 years). Subjects were given laptop computers to take home and were asked to perform 40 hours of training or 40 hours of commercial computer games over 8 weeks. We examined cognitive measures recommended by the Measurement and Treatment Research to Improve Cognition in Schizophrenia initiative (MATRICS), symptoms, and functioning. We also assessed baseline reward anticipation to index motivational system functioning and measured changes in auditory processing speed after 20 hours of training to assess target engagement.

resultsAuditory training subjects demonstrated significant improvements in global cognition, verbal memory, and problem solving compared with those of computer games control subjects. Both groups showed a slight but significant decrease in symptoms and no change in functional outcome measures. Training-induced cognitive gains at posttraining showed significant associations with reward anticipation at baseline and with improvement in auditory processing speed at 20 hours.

conclusionNeuroscience-informed cognitive training via laptop computer represents a promising treatment approach for cognitive dysfunction in early schizophrenia. An individual's baseline motivational system functioning (reward anticipation), and ability to engage in auditory processing speed improvement, may represent important predictors of treatment outcome. Future studies must investigate whether cognitive training improves functioning and how best to integrate it into critical psychosocial interventions.

Indexed as

Auditory PerceptionNeuronal PlasticitySchizophrenic PsychologyVerbal LearningAdolescentAdultAntipsychotic AgentsCognition DisordersCognitive Behavioral TherapyCombined Modality TherapyDouble-Blind MethodFemaleHumansMaleMemoryProblem SolvingAntipsychotic Agentscognitive remediationcognitive trainingearly psychosisfirst-episode schizophreniamotivation

Identifiers

PMID24444862
PMCPMC4266283

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.