Evidence map›Paper›PMID 24444806›Full record

ArticleNeurobiology of aging2014

Interaction of APOE genotype and testosterone on episodic memory in middle-aged men.

Matthew S Panizzon, Richard Hauger, Hong Xian, Eero Vuoksimaa, Kelly M Spoon, Sally P Mendoza, Kristen C Jacobson, Terrie Vasilopoulos, Brinda K Rana, Ruth McKenzie and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Testosterone, cognitive decline and dementia in ageing men.Reviews in endocrine & metabolic disorders · 2022
    Review
  7. Androgens and Adult Neurogenesis in the Hippocampus.Androgens: clinical research and therapeutics · 2021
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager-horticulturalists with a high parasite burden.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017
    Article
  15. Obesity and sex interact in the regulation of Alzheimer's disease.Neuroscience and biobehavioral reviews · 2016
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 2 countries.

Matthew S PanizzonDepartment of Psychiatry, University of California, San Diego, CA, USA; Twin Research Laboratory, Center for Behavioral Genomics, University of California, San Diego, CA, USA. Electronic address: mspanizz@ucsd.edu.
Richard HaugerDepartment of Psychiatry, University of California, San Diego, CA, USA; VA San Diego Healthcare System, CA, USA; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, USA.
Hong XianDepartment of Biostatistics, St. Louis University, College for Public Health & Social Justice, St. Louis, MO, USA; Research Service, St. Louis Veterans Affairs Medical Center, St. Louis, MO.
Eero VuoksimaaDepartment of Psychiatry, University of California, San Diego, CA, USA; Twin Research Laboratory, Center for Behavioral Genomics, University of California, San Diego, CA, USA; Department of Public Health, University of Helsinki, Helsinki, Finland.
Kelly M SpoonComputational Science Research Center, San Diego State University, San Diego, CA, USA.
Sally P MendozaDepartment of Psychology, University of California, Davis, CA, USA.
Kristen C JacobsonDepartment of Psychiatry, University of Chicago, Chicago, IL, USA.
Terrie VasilopoulosDepartment of Psychiatry, University of Chicago, Chicago, IL, USA.
Brinda K RanaDepartment of Psychiatry, University of California, San Diego, CA, USA; Twin Research Laboratory, Center for Behavioral Genomics, University of California, San Diego, CA, USA.
Ruth McKenzieDepartment of Psychology, Boston University, Boston, MA, USA.
Jeanne M McCafferyDepartment of Psychiatry and Human Behavior, The Miriam Hospital and Warren Alpert School of Medicine at Brown University, Providence, RI, USA.
Michael J LyonsDepartment of Psychology, Boston University, Boston, MA, USA.
William S KremenDepartment of Psychiatry, University of California, San Diego, CA, USA; Twin Research Laboratory, Center for Behavioral Genomics, University of California, San Diego, CA, USA; VA San Diego Healthcare System, CA, USA; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, USA.
Carol E FranzDepartment of Psychiatry, University of California, San Diego, CA, USA; Twin Research Laboratory, Center for Behavioral Genomics, University of California, San Diego, CA, USA.
University of California, San Diego · USBoston University · USUniversity of Chicago · USVA San Diego Healthcare System · USBrown University · USSaint Louis University · USSan Diego State University · USUniversity of California, Davis · USUniversity of Helsinki · FI

Funding

The VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3M
Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
The VETSA Longitudinal Twin Study of Cognition and AgingR01AG018384 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LYONS, MICHAEL J. · 2002 to 2012
$9.8M
The VETSA longitudinal twin study of cognition and agingR01AG018386 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2002 to 2012
$9.7M
The VETSA Longitudinal Twin Study of Cortisol and AgingR01AG022982 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2004 to 2007
$2.6M
Genetic and Epigenetic Factors of Age-Related Cognitive Decline - A Twin StudyK01AG035031 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RANA, BRINDA K · 2010 to 2014
$614k
NCATS NIH HHS UL1 TR000430NIA NIH HHS AG018384NIA NIH HHS AG018386NIA NIH HHS AG022381NIA NIH HHS AG022982NIA NIH HHS K01 AG035031NIA NIH HHS R01 AG018384NIA NIH HHS R01 AG018386NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG022982
6 · The paper itself

Abstract

Age-related changes in testosterone are believed to be a key component of the processes that contribute to cognitive aging in men. The APOE-ε4 allele may interact with testosterone and moderate the hormone's association with cognition. The goals of the present study were to examine the degree to which free testosterone is associated with episodic memory in a community-based sample of middle-aged men, and examine the potential interaction between free testosterone and the APOE-ε4 allele. Data were used from 717 participants in the Vietnam Era Twin Study of Aging. Average age was 55.4 years (standard deviation = 2.5). Significant positive associations were observed between free testosterone level and verbal episodic memory, as well as a significant interaction between free testosterone and APOE-ε4 status. In ε4 carriers free testosterone was positively associated with verbal episodic memory performance (story recall), whereas no association was observed in ε4 noncarriers. Results support the hypothesis that APOE-ε4 status increases susceptibility to other risk factors, such as low testosterone, which may ultimately contribute to cognitive decline or dementia.

Indexed as

AllelesMemory, EpisodicAgingApolipoprotein E4CognitionCognition DisordersDementiaGenetic Predisposition to DiseaseHeterozygoteHumansMaleMiddle AgedRisk FactorsTestosteroneTwin Studies as TopicVerbal BehaviorApolipoprotein E4TestosteroneAPOEEpisodic memoryGene-hormone interactionMiddle-ageTestosterone

Identifiers

PMID24444806
PMCPMC3980008
OpenAlexW2030194637

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.