Evidence map›Paper›PMID 24444601›Full record

ArticleFEBS letters2014

Identification of an arylalkylamine N-acyltransferase from Drosophila melanogaster that catalyzes the formation of long-chain N-acylserotonins.

Daniel R Dempsey, Kristen A Jeffries, Ryan L Anderson, Anne-Marie Carpenter, Santiago Rodriquez Opsina, David J Merkler

Abstract read
In one paragraph

Article in FEBS letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Insect Lipids: Structure, Classification and Function.Advances in experimental medicine and biology · 2026
    Review
  3. Article
  4. Review
  5. The Biosynthesis and Metabolism of theFrontiers in molecular biosciences · 2021
    Review
  6. Article
  7. G3 (Bethesda, Md.) · 2020
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Bm-iAANAT and its potential role in fatty acid amide biosynthesis in Bombyx mori.Prostaglandins, leukotrienes, and essential fatty acids · 2018
    Article
  13. Insect ArylalkylamineFrontiers in molecular biosciences · 2018
    Review
  14. Article
  15. Journal of biology and nature · 2017
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Daniel R DempseyDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA.
Kristen A JeffriesDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA.
Ryan L AndersonDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA.
Anne-Marie CarpenterDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA.
Santiago Rodriquez OpsinaDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA.
David J MerklerDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA. Electronic address: merkler@usf.edu.

Funding

Glycine N-AcyltransferasesR03DA034323 · NIDA · UNIVERSITY OF SOUTH FLORIDA · PI MERKLER, DAVID J · 2012 to 2013
$136k
NIDA NIH HHS R03 DA034323NIDA NIH HHS R03-DA034323
6 · The paper itself

Abstract

Arylalkylamine N-acyltransferase-like 2(2) (AANATL2) from Drosophila melanogaster was expressed and shown to catalyze the formation of long-chain N-acylserotonins and N-acydopamines. Subsequent identification of endogenous amounts of N-acylserotonins and colocalization of these fatty acid amides and AANATL2 transcripts gives supporting evidence that AANATL2 has a role in the biosynthetic formation of these important cell signalling lipids.

Indexed as

BiocatalysisAcyltransferasesAnimalsDrosophila melanogasterGene Expression Regulation, EnzymologicOrgan SpecificityRNA, MessengerSerotoninAcyltransferasesRNA, MessengerSerotoninArylalkylamine N-acetyltransferaseArylalkylamine N-acyltransferaseDrosophila melanogasterN-acyldopamineN-acylserotoninSteady-state kineticsThorax-abdomen

Identifiers

PMID24444601
PMCPMC3952154

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.