Evidence map›Paper›PMID 24444524›Full record

ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2014

Role of endorectal MR imaging and MR spectroscopic imaging in defining treatable intraprostatic tumor foci in prostate cancer: quantitative analysis of imaging contour compared to whole-mount histopathology.

Mekhail Anwar, Antonio C Westphalen, Adam J Jung, Susan M Noworolski, Jeffry P Simko, John Kurhanewicz, Mack Roach, Peter R Carroll, Fergus V Coakley

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PubMed Full text at PMC Publisher
In one paragraph

Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Mekhail AnwarDepartment of Radiation Oncology, University of California San Francisco, USA. Electronic address: anwarme@radonc.ucsf.edu.
Antonio C WestphalenDepartment of Radiology and Biomedical Imaging, University of California San Francisco, USA.
Adam J JungDepartment of Radiology and Biomedical Imaging, University of California San Francisco, USA.
Susan M NoworolskiDepartment of Radiology and Biomedical Imaging, University of California San Francisco, USA; UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, USA; The Graduate Group in Bioengineering, University of California San Francisco, USA; University of California Berkeley, USA.
Jeffry P SimkoDepartment of Anatomic Pathology, University of California San Francisco, USA; UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, USA.
John KurhanewiczDepartment of Radiology and Biomedical Imaging, University of California San Francisco, USA; UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, USA; The Graduate Group in Bioengineering, University of California San Francisco, USA; University of California Berkeley, USA.
Mack RoachDepartment of Radiation Oncology, University of California San Francisco, USA; UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, USA.
Peter R CarrollDepartment of Urology, University of California San Francisco, USA; UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, USA.
Fergus V CoakleyDepartment of Radiology and Biomedical Imaging, University of California San Francisco, USA; Department of Urology, University of California San Francisco, USA; UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, USA.
University of California, San Francisco · US

Funding

CTSA: K12 COMPONENTKL2RR024130 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$19.3M
MR-guided focused ultrasound systemS10RR028911 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COAKLEY, FERGUS V · 2010 to 2010
$1.4M
DCE MRI to Improve Prostate Cancer Identification and CharacterizationR01CA148708 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NOWOROLSKI, SUSAN M · 2010 to 2014
$1.3M
NCI NIH HHS R01 CA148708NCRR NIH HHS 1S10RR028911-01NCRR NIH HHS KL2 RR024130NCRR NIH HHS S10 RR028911
6 · The paper itself

Abstract

purposeTo investigate the role of endorectal MR imaging and MR spectroscopic imaging in defining the contour of treatable intraprostatic tumor foci in prostate cancer, since targeted therapy requires accurate target volume definition. MATERIALS AND

methodsWe retrospectively identified 20 patients with prostate cancer who underwent endorectal MR imaging and MR spectroscopic imaging prior to radical prostatectomy and subsequent creation of detailed histopathological tumor maps from whole-mount step sections. Two experienced radiologists independently reviewed all MR images and electronically contoured all suspected treatable (≥0.5 cm(3)) tumor foci. Deformable co-registration in MATLAB was used to calculate the margin of error between imaging and histopathological contours at both capsular and non-capsular surfaces and the treatment margin required to ensure at least 95% tumor coverage.

resultsHistopathology showed 17 treatable tumor foci in 16 patients, of which 8 were correctly identified by both readers and an additional 2 were correctly identified by reader 2. For all correctly identified lesions, both readers accurately identified that tumor contacted the prostatic capsule, with no error in contour identification. On the non-capsular border, the median distance between the imaging and histopathological contour was 1.4mm (range, 0-12). Expanding the contour by 5mm at the non-capsular margin included 95% of tumor volume not initially covered within the MR contour.

conclusionsEndorectal MR imaging and MR spectroscopic imaging can be used to accurately contour treatable intraprostatic tumor foci; adequate tumor coverage is achieved by expanding the treatment contour at the non-capsular margin by 5mm.

Indexed as

AgedDiagnostic ImagingHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMiddle AgedProstatectomyProstatic NeoplasmsRetrospective StudiesTumor BurdenDominant intraprostatic lesionDose escalationFocal therapyMRIMRSIProstate cancer

Identifiers

PMID24444524
PMCPMC3969841
OpenAlexW2021871502

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.