Evidence map›Paper›PMID 24444366›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2014

Shared familial transmission of autism spectrum and attention-deficit/hyperactivity disorders.

Erica D Musser, Elizabeth Hawkey, Svetlana S Kachan-Liu, Paul Lees, Jean-Baptiste Roullet, Katrina Goddard, Robert D Steiner, Joel T Nigg

Open access · greenAbstract read
In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 3 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 3 syntheses or guidelines pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Identification of Early Temperament Profiles in Infants at Elevated Likelihood for Autism and Attention-Deficit/Hyperactivity Disorder.Clinical psychological science : a journal of the Association for Psychological Science · 2026
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  11. Connectome-based symptom mapping andmedRxiv : the preprint server for health sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Erica D MusserOregon Health & Science University, Sam Jackson Park Road, Portland, OR, USA; University of Oregon, Eugene, OR, USA.
Elizabeth Hawkey
Svetlana S Kachan-Liu
Paul Lees
Jean-Baptiste Roullet
Katrina Goddard
Robert D Steiner
Joel T Nigg
Oregon Health & Science University · USKaiser Permanente · USJohns Hopkins Medicine · USMarshfield Clinic · US

Funding

ADHD heterogeneity, mechanisms, and risk profileR37MH059105 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI NIGG, JOEL T · 2014 to 2023
$7.0M
Brain trajectories in ADHDR01MH115357 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI FAIR, DAMIEN A, NIGG, JOEL T · 2017 to 2021
$3.8M
NEUROPSYCHOLOGICAL AND FAMILIAL MARKERS FOR CHILD ADHDR01MH059105 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI NIGG, JOEL T · 1999 to 2012
$3.3M
NIMH NIH HHS R01 MH059105NIMH NIH HHS R01 MH115357NIMH NIH HHS R01-MH59105NIMH NIH HHS R37 MH059105
6 · The paper itself

Abstract

backgroundTo determine whether familial transmission is shared between autism spectrum disorders and attention-deficit/hyperactivity disorder, we assessed the prevalence, rates of comorbidity, and familial transmission of both disorders in a large population-based sample of children during a recent 7 year period.

methodsStudy participants included all children born to parents with the Kaiser Permanente Northwest (KPNW) Health Plan between 1 January 1998 and 31 December 2004 (n = 35,073). Children and mothers with physician-identified autism spectrum disorders (ASD) and/or attention-deficit/hyperactivity disorder (ADHD) were identified via electronic medical records maintained for all KPNW members.

resultsAmong children aged 6-12 years, prevalence was 2.0% for ADHD and 0.8% for ASD; within those groups, 0.2% of the full sample (19% of the ASD sample and 9.6% of the ADHD sample) had co-occurring ASD and ADHD, when all children were included. When mothers had a diagnosis of ADHD, first born offspring were at 6-fold risk of ADHD alone (OR = 5.02, p < .0001) and at 2.5-fold risk of ASD alone (OR = 2.52, p < .01). Results were not accounted for by maternal age, child gestational age, child gender, and child race.

conclusionsAutism spectrum disorders shares familial transmission with ADHD. ADHD and ASD have a partially overlapping diathesis.

Indexed as

Attention Deficit Disorder with HyperactivityChildChild Development Disorders, PervasiveComorbidityFemaleGenetic Predisposition to DiseaseHumansMaleMothersNorthwestern United StatesPrevalenceAttention-deficit/hyperactivity disorderautism spectrum disordershared familial transmission

Identifiers

PMID24444366
PMCPMC4211282
OpenAlexW2117008480

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.