ArticleAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology2014
Aluminium adjuvants and adverse events in sub-cutaneous allergy immunotherapy.
Article in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Ganoderma lucidum spore powder enhances IFN-α-mediated antiviral capacity of COVID-19 vaccine boosters revealed by single-cell multi-omics sequencing.Journal of advanced research · 2026Article
- Favorable safety and immunogenicity of a combined quadrivalent influenza and recombinant SARS-CoV-2 vaccine in Sprague-Dawley rats for both primary and booster immunization.Frontiers in immunology · 2026Article
- The Structural Characterization of a Polysaccharide from the Dried Root ofInternational journal of molecular sciences · 2024Article
- Local and Systemic Hypoxia as Inductors of Increased Aluminum and Iron Brain Accumulation Promoting the Onset of Alzheimer's Disease.Biological trace element research · 2023Review
- Clinical and experimental treatment of allergic asthma with an emphasis on allergen immunotherapy and its mechanisms.Clinical and experimental immunology · 2023Article
- Sonography of subcutaneous nodules following immunization with histopathological correlation: a three-case series.Journal of ultrasound · 2022Article
- Evaluation of a Novel Adjuvanted Vaccine for Ultrashort Regimen Therapy ofFrontiers in immunology · 2022Article
- Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication.Emergency medicine international · 2022Review
- Cytokines profile in neonatal and adult wild-type mice post-injection of U. S. pediatric vaccination schedule.Brain, behavior, & immunity - health · 2021Article
- The Role of Bacterial Membrane Vesicles in the Dissemination of Antibiotic Resistance and as Promising Carriers for Therapeutic Agent Delivery.Microorganisms · 2020Review
- The size of micro-crystalline tyrosine (MCT®) influences its recognition and uptake by THP-1 macrophagesRSC advances · 2019Article
- DOPS Adjuvant Confers Enhanced Protection against Malaria for VLP-TRAP Based Vaccines.Diseases (Basel, Switzerland) · 2018Article
- Outer Membrane Vesicles: Current Status and Future Direction of These Novel Vaccine Adjuvants.Frontiers in microbiology · 2018Review
- Cutaneous vaccination with coated microneedles prevents development of airway allergy.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Allergen-specific immunotherapy of Hymenoptera venom allergy - also a matter of diagnosis.Human vaccines & immunotherapeutics · 2017Review
- Microcrystalline Tyrosine (MCTVaccines · 2017Article
- Article
- Behavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil.Immunologic research · 2017Article
- Aluminium in Allergies and Allergen immunotherapy.The World Allergy Organization journal · 2015Article
- Why industry propaganda and political interference cannot disguise the inevitable role played by human exposure to aluminum in neurodegenerative diseases, including Alzheimer's disease.Frontiers in neurology · 2014Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sub-cutaneous immunotherapy is an effective treatment for allergy. It works by helping to modify or re-balance an individual's immune response to allergens and its efficacy is greatly improved by the use of adjuvants, most commonly, aluminium hydroxide. Aluminium salts have been used in allergy therapy for many decades and are assumed to be safe with few established side-effects. This assumption belies their potency as adjuvants and their potential for biological reactivity both at injection sites and elsewhere in the body. There are very few data purporting to the safety of aluminium adjuvants in allergy immunotherapy and particularly so in relation to longer term health effects. There are, if only few, published reports of adverse events following allergy immunotherapy and aluminium adjuvants are the prime suspects in the majority of such incidents. Aluminium adjuvants are clearly capable of initiating unwanted side effects in recipients of immunotherapy and while there is as yet no evidence that such are commonplace it is complacent to consider aluminium salts as harmless constituents of allergy therapies. Future research should establish the safety of the use of aluminium adjuvants in sub-cutaneous allergy immunotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.