ArticleThe European journal of neuroscience2014
Role of Go/i subgroup of G proteins in olfactory signaling of Drosophila melanogaster.
Article in The European journal of neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Hawkmoth Pheromone Transduction Involves G-Protein-Dependent Phospholipase Cβ Signaling.eNeuro · 2025Article
- Rational engineering approaches for establishing insect olfaction reporters in yeast.Biotechnology notes (Amsterdam, Netherlands) · 2023Article
- Heterologous investigation of metabotropic and ionotropic odorant receptors in ab3A neurons ofFrontiers in molecular biosciences · 2023Article
- Modulation of the NO-cGMP pathway has no effect on olfactory responses in theFrontiers in cellular neuroscience · 2023Article
- Homeostasis of Mitochondrial CaInsects · 2022Article
- Functional properties of insect olfactory receptors: ionotropic receptors and odorant receptors.Cell and tissue research · 2021Review
- Strength in diversity: functional diversity among olfactory neurons of the same type.Journal of bioenergetics and biomembranes · 2019Review
- High capacity in G protein-coupled receptor signaling.Nature communications · 2018Article
- Tuning Insect Odorant Receptors.Frontiers in cellular neuroscience · 2018Article
- TheFrontiers in cellular neuroscience · 2018Article
- Current Status on the Functional Characterization of Chemosensory Receptors ofFrontiers in behavioral neuroscience · 2018Article
- The Two Main Olfactory Receptor Families inFrontiers in cellular neuroscience · 2018Review
- Take time: odor coding capacity across sensory neurons increases over time in Drosophila.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Article
- Article
- Morphological and Transcriptomic Analysis of a Beetle Chemosensory System Reveals a Gnathal Olfactory Center.BMC biology · 2016Article
- Calmodulin Affects Sensitization of Drosophila melanogaster Odorant Receptors.Frontiers in cellular neuroscience · 2016Article
- Drosophila Chemoreceptors: A Molecular Interface Between the Chemical World and the Brain.Trends in genetics : TIG · 2015Review
- Molecular Cloning and Characterization of G Alpha Proteins from the Western Tarnished Plant Bug, Lygus hesperus.Insects · 2014Article
- High-speed odor transduction and pulse tracking by insect olfactory receptor neurons.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- An inhibitor of Na(+)/Ca(2+) exchange blocks activation of insect olfactory receptors.Biochemical and biophysical research communications · 2014Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular signaling in insect olfactory receptor neurons remains unclear, with both metabotropic and ionotropic components being discussed. Here, we investigated the role of heterotrimeric Go and Gi proteins using a combined behavioral, in vivo and in vitro approach. Specifically, we show that inhibiting Go in sensory neurons by pertussis toxin leads to behavioral deficits. We heterologously expressed the olfactory receptor dOr22a in human embryonic kidney cells (HEK293T). Stimulation with an odor led to calcium influx, which was amplified via calcium release from intracellular stores. Subsequent experiments indicated that the signaling was mediated by the Gβγ subunits of the heterotrimeric Go/i proteins. Finally, using in vivo calcium imaging, we show that Go and Gi contribute to odor responses both for the fast (phasic) as for the slow (tonic) response component. We propose a transduction cascade model involving several parallel processes, in which the metabotropic component is activated by Go and Gi , and uses Gβγ.
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