ArticleGenetics2014
Genomic signature of adaptation to climate in Medicago truncatula.
Article in Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed.
- Environmental Association Analyses in Plants and the Influence of Methodological Decisions.Molecular ecology · 2026Review
- A global assembly of landrace oat (Avena sativa L.) accessions is a discovery resource for adaptive variation, association mapping, and trait deployment.G3 (Bethesda, Md.) · 2025Article
- Environmental data provide marginal benefit for predicting climate adaptation.PLoS genetics · 2025Article
- Environmental genome-wide association studies across precipitation regimes reveal that the E3 ubiquitin ligase MBR1 regulates plant adaptation to rainy environments.Plant communications · 2024Article
- Genome-wide DNA methylation and their transgenerational pattern differ in Arabidopsis thaliana populations originated along the elevation of West Himalaya.BMC plant biology · 2024Article
- The genetic architecture of repeated local adaptation to climate in distantly related plants.Nature ecology & evolution · 2024Article
- From common gardens to candidate genes: exploring local adaptation to climate in red spruce.The New phytologist · 2023Article
- Genetic diversity and local adaption of alfalfa populations (Medicago sativa L.) under long-term grazing.Scientific reports · 2023Article
- Genotype-environment associations to reveal the molecular basis of environmental adaptation.The Plant cell · 2023Article
- Population structure of wild soybean (PeerJ · 2023Article
- Genomic-environmental associations in wild cranberry (Vaccinium macrocarpon Ait.).G3 (Bethesda, Md.) · 2022Article
- Worldwide Selection Footprints for Drought and Heat in Bread Wheat (Plants (Basel, Switzerland) · 2022Article
- Evolution of flowering time in a selfing annual plant: Roles of adaptation and genetic drift.Ecology and evolution · 2022Article
- Genome-Environment Associations, an Innovative Tool for Studying Heritable Evolutionary Adaptation in Orphan Crops and Wild Relatives.Frontiers in genetics · 2022Review
- Genomic and common garden approaches yield complementary results for quantifying environmental drivers of local adaptation in rubber rabbitbrush, a foundational Great Basin shrub.Evolutionary applications · 2021Article
- Evaluation of environmental factors affecting the genetic diversity, genetic structure, and the potential distribution ofEcology and evolution · 2021Article
- Salt Stress Enhances Early Symbiotic Gene Expression inMolecular plant-microbe interactions : MPMI · 2021Article
- Powerful detection of polygenic selection and evidence of environmental adaptation in US beef cattle.PLoS genetics · 2021Article
- Review
- Genetic architecture and adaptation of flowering time among environments.The New phytologist · 2021Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Local adaptation and adaptive clines are pervasive in natural plant populations, yet the effects of these types of adaptation on genomic diversity are not well understood. With a data set of 202 accessions of Medicago truncatula genotyped at almost 2 million single nucleotide polymorphisms, we used mixed linear models to identify candidate loci responsible for adaptation to three climatic gradients-annual mean temperature (AMT), precipitation in the wettest month (PWM), and isothermality (ITH)-representing the major axes of climate variation across the species' range. Loci with the strongest association to these climate gradients tagged genome regions with high sequence similarity to genes with functional roles in thermal tolerance, drought tolerance, or resistance to herbivores of pathogens. Genotypes at these candidate loci also predicted the performance of an independent sample of plant accessions grown in climate-controlled conditions. Compared to a genome-wide sample of randomly drawn reference SNPs, candidates for two climate gradients, AMT and PWM, were significantly enriched for genic regions, and genome segments flanking genic AMT and PWM candidates harbored less nucleotide diversity, elevated differentiation between haplotypes carrying alternate alleles, and an overrepresentation of the most common haplotypes. These patterns of diversity are consistent with a history of soft selective sweeps acting on loci underlying adaptation to climate, but not with a history of long-term balancing selection.
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