ArticleGenome biology and evolution2014
Early divergence, broad distribution, and high diversity of animal chitin synthases.
Article in Genome biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 80 citations in OpenAlex.
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- Sequential host-bacteria and bacteria-bacteria interactions determine the microbiome establishment of Nematostella vectensis.Microbiome · 2023Article
- Unexpected Distribution of Chitin andBiomolecules · 2023Article
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- Uniaxial orientation of β-chitin nanofibres used as an organic framework in the scales of a hot vent snail.Journal of the Royal Society, Interface · 2022Article
- Transcriptome analysis of the bivalve Placuna placenta mantle reveals potential biomineralization-related genes.Scientific reports · 2022Article
- Progress in Modern Marine Biomaterials Research.Marine drugs · 2020Review
- The Scaly-foot Snail genome and implications for the origins of biomineralised armour.Nature communications · 2020Article
- Chitin-based barrier immunity and its loss predated mucus-colonization by indigenous gut microbiota.Nature communications · 2018Article
- Novel Genes, Ancient Genes, and Gene Co-Option Contributed to the Genetic Basis of the Radula, a Molluscan Innovation.Molecular biology and evolution · 2018Article
- Chitin protects the gut epithelial barrier in a protochordate model of DSS-induced colitis.Biology open · 2018Article
- Genome-Wide Screening and Functional Analysis Reveal That the Specific microRNA nlu-miR-173 Regulates Molting by Targeting Ftz-F1 inFrontiers in physiology · 2018Article
- Article
- Evolution of the chitin synthase gene family correlates with fungal morphogenesis and adaption to ecological niches.Scientific reports · 2017Article
- Genome-wide analyses of chitin synthases identify horizontal gene transfers towards bacteria and allow a robust and unifying classification into fungi.BMC evolutionary biology · 2016Article
- Evolution and Functional Insights of Different Ancestral Orthologous Clades of Chitin Synthase Genes in the Fungal Tree of Life.Frontiers in plant science · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Even though chitin is one of the most abundant biopolymers in nature, current knowledge on chitin formation is largely based only on data from fungi and insects. This study reveals unanticipated broad taxonomic distribution and extensive diversification of chitin synthases (CSs) in Metazoa, shedding new light on the relevance of chitin in animals and suggesting unforeseen complexity of chitin synthesis in many groups. We uncovered robust orthologs to insect type CSs in several representatives of deuterostomes, which generally are not thought to possess chitin. This suggests a broader distribution and function of chitin in this branch of the animal kingdom. We characterize a new CS type present not only in basal metazoans such as sponges and cnidarians but also in several bilaterian representatives. The most extensive diversification of CSs took place during emergence of lophotrochozoans, the third large group of protostomes next to arthropods and nematodes, resulting in coexistence of up to ten CS paralogs in molluscs. Independent fusion to different kinds of myosin motor domains in fungi and lophotrochozoans points toward high relevance of CS interaction with the cytoskeleton for fine-tuned chitin secretion. Given the fundamental role that chitin plays in the morphology of many animals, the here presented CS diversification reveals many evolutionary complexities. Our findings strongly suggest a very broad and multifarious occurrence of chitin and question an ancestral role as cuticular component. The molecular mechanisms underlying regulation of animal chitin synthesis are most likely far more complex and diverse than existing data from insects suggest.
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