Evidence map›Paper›PMID 24443405›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2014

Oxidative balance score, colorectal adenoma, and markers of oxidative stress and inflammation.

So Yeon J Kong, Roberd M Bostick, W Dana Flanders, William M McClellan, Bharat Thyagarajan, Myron D Gross, Suzanne Judd, Michael Goodman

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 4 pooled it
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 4 syntheses or guidelines pooled it, 93 citations in OpenAlex.

  1. Pooled it
  2. A Review ofNutrients · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

So Yeon J KongAuthors' Affiliations: Department of Epidemiology, Rollins School of Public Health; Winship Cancer Institute, Emory University, Atlanta, Georgia; Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, Minneapolis, Minnesota; and Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama.
Roberd M Bostick
W Dana Flanders
William M McClellan
Bharat Thyagarajan
Myron D Gross
Suzanne Judd
Michael Goodman
University of Alabama at Birmingham · USUniversity of Minnesota · USEmory University · US

Funding

Oxidative Stress, DNA Repair & Colorectal Adenoma RiskR01CA116795 · NCI · EMORY UNIVERSITY · PI GOODMAN, MICHAEL · 2007 to 2009
$869k
DIET, CELL PROLIFERATION, AND COLON NEOPLASIA STUDYR01CA066539 · NCI · WAKE FOREST UNIVERSITY · PI BOSTICK, ROBERD · 1994 to 1996
–
NCI NIH HHS CA116795NCI NIH HHS R01 CA066539NCI NIH HHS R01 CA116795
6 · The paper itself

Abstract

backgroundAn oxidative balance score (OBS) that combines pro- and antioxidant exposures was previously reported to be associated with incident sporadic colorectal adenoma. We extend the previous analyses by assessing associations of the OBS and colorectal adenoma with circulating biomarkers of oxidative stress [F2-isoprostanes (FIP) and fluorescent oxidation products (FOP)], and inflammation [C-reactive protein (CRP)].

methodsUsing pooled data from two previously conducted colonoscopy-based case-control studies of incident, sporadic colorectal adenoma (n = 365), the OBS was constructed and divided into three approximately equal intervals, with the lowest interval used as the reference. Biomarker levels were dichotomized as "high" versus "low" based on the median values among controls. Multivariable logistic regression was used to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs).

resultsFor the OBS-adenoma association, the ORs (95% CIs) for the middle and highest (relative to the lowest) score intervals were 0.81 (0.46-1.43) and 0.39 (0.17-0.89), respectively. The corresponding OBS category-specific ORs (95% CIs) were 0.50 (0.25-1.01) and 0.25 (0.10-0.65) for FIP, 2.01 (1.13-3.75) and 3.48 (1.51-8.02) for FOP, and 0.57 (0.31-1.04) and 0.21 (0.09-0.49) for CRP. The ORs (95% CIs) reflecting associations of adenoma with high levels of FIP, FOP, and CRP were 1.89 (1.08-3.30), 1.82 (1.11-2.99), and 1.45 (0.88-2.40), respectively.

conclusionsAs hypothesized, the OBS was inversely associated with colorectal adenoma and circulating FIP and CRP levels. The reason for the unexpected direct OBS-FOP association is unknown. IMPACT: These data support the use of combined measures of pro- and antioxidant exposures in studies of colorectal neoplasia.

Indexed as

AdenomaAdultAgedCase-Control StudiesColorectal NeoplasmsFemaleHumansInflammationMaleMiddle AgedOxidation-ReductionOxidative StressRisk Factors

Identifiers

PMID24443405
PMCPMC3959731
OpenAlexW2133421024

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.