ArticleJournal of molecular neuroscience : MN2014
Study of the spatial correlation between neuronal activity and BOLD fMRI responses evoked by sensory and channelrhodopsin-2 stimulation in the rat somatosensory cortex.
Article in Journal of molecular neuroscience : MN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Magnetogenetic stimulation inside MRI induces spontaneous and evoked changes in neural circuits activity in rats.Frontiers in neuroscience · 2024Article
- Magnetogenetic stimulation inside MRI induces spontaneous and evoked changes in neural circuits activity in rats.bioRxiv : the preprint server for biology · 2023Article
- Cerebrospinal fluid solute transport associated with sensorimotor brain activity in rodents.Scientific reports · 2023Article
- Dynamic 3D imaging of cerebral blood flow in awake mice using self-supervised-learning-enhanced optical coherence Doppler tomography.Communications biology · 2023Article
- Changes in Neuronal Activity in the Anterior Cingulate Cortex and Primary Somatosensory Cortex With Nonlinear Burst and Tonic Spinal Cord Stimulation.Neuromodulation : journal of the International Neuromodulation Society · 2020Article
- Temporal stability of fMRI in medetomidine-anesthetized rats.Scientific reports · 2019Article
- Foundations of layer-specific fMRI and investigations of neurophysiological activity in the laminarized neocortex and olfactory bulb of animal models.NeuroImage · 2019Review
- Multimodal Evaluation of TMS - Induced Somatosensory Plasticity and Behavioral Recovery in Rats With Contusion Spinal Cord Injury.Frontiers in neuroscience · 2019Article
- Optical imaging and modulation of neurovascular responses.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Review
- From unspecific to adjusted, how the BOLD response in the rat hippocampus develops during consecutive stimulations.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Review of mesoscopic optical tomography for depth-resolved imaging of hemodynamic changes and neural activities.Neurophotonics · 2017Review
- High-Resolution Functional Connectivity Density: Hub Locations, Sensitivity, Specificity, Reproducibility, and Reliability.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Optogenetic fMRI in the mouse hippocampus: Hemodynamic response to brief glutamatergic stimuli.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2016Article
- Probing Neural Transplant Networks In Vivo with Optogenetics and Optogenetic fMRI.Stem cells international · 2016Review
- Transcranial magnetic stimulation facilitates neurorehabilitation after pediatric traumatic brain injury.Scientific reports · 2015Article
- Neural and hemodynamic responses to optogenetic and sensory stimulation in the rat somatosensory cortex.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- Contributions and complexities from the use of in vivo animal models to improve understanding of human neuroimaging signals.Frontiers in neuroscience · 2014Review
- Multi-session delivery of synchronous rTMS and sensory stimulation induces long-term plasticity.Brain stimulationArticle
- Non-invasive neuromodulation using rTMS and the electromagnetic-perceptive gene (EPG) facilitates plasticity after nerve injury.Brain stimulationArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
In this work, we combined optogenetic tools with high-resolution blood oxygenation level-dependent functional MRI (BOLD fMRI), electrophysiology, and optical imaging of cerebral blood flow (CBF), to study the spatial correlation between the hemodynamic responses and neuronal activity. We first investigated the spatial and temporal characteristics of BOLD fMRI and the underlying neuronal responses evoked by sensory stimulations at different frequencies. The results demonstrated that under dexmedetomidine anesthesia, BOLD fMRI and neuronal activity in the rat primary somatosensory cortex (S1) have different frequency-dependency and distinct laminar activation profiles. We then found that localized activation of channelrhodopsin-2 (ChR2) expressed in neurons throughout the cortex induced neuronal responses that were confined to the light stimulation S1 region (<500 μm) with distinct laminar activation profile. However, the spatial extent of the hemodynamic responses measured by CBF and BOLD fMRI induced by both ChR2 and sensory stimulation was greater than 3 mm. These results suggest that due to the complex neurovascular coupling, it is challenging to determine specific characteristics of the underlying neuronal activity exclusively from the BOLD fMRI signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.