ArticleMagnetic resonance in medicine2014
Microstructural origins of gadolinium-enhanced susceptibility contrast and anisotropy.
Article in Magnetic resonance in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Evaluation of the Blood-Brain Barrier, Demyelination, and Neurodegeneration in Paramagnetic Rim Lesions in Multiple Sclerosis on 7 Tesla MRI.Journal of magnetic resonance imaging : JMRI · 2024Article
- Asymmetric susceptibility tensor imaging.Magnetic resonance in medicine · 2021Article
- Mapping the peripheral nervous system in the whole mouse via compressed sensing tractography.Journal of neural engineering · 2021Article
- Probing demyelination and remyelination of the cuprizone mouse model using multimodality MRI.Journal of magnetic resonance imaging : JMRI · 2019Article
- MRI gradient-echo phase contrast of the brain at ultra-short TE with off-resonance saturation.NeuroImage · 2018Article
- Tissue magnetic susceptibility mapping as a marker of tau pathology in Alzheimer's disease.NeuroImage · 2017Article
- Joint eigenvector estimation from mutually anisotropic tensors improves susceptibility tensor imaging of the brain, kidney, and heart.Magnetic resonance in medicine · 2017Article
- Magnetic susceptibility anisotropy outside the central nervous system.NMR in biomedicine · 2017Review
- Susceptibility tensor imaging (STI) of the brain.NMR in biomedicine · 2017Review
- Imaging whole-brain cytoarchitecture of mouse with MRI-based quantitative susceptibility mapping.NeuroImage · 2016Article
- Dynamic contrast-enhanced quantitative susceptibility mapping with ultrashort echo time MRI for evaluating renal function.American journal of physiology. Renal physiology · 2016Article
- Streaking artifact reduction for quantitative susceptibility mapping of sources with large dynamic range.NMR in biomedicine · 2015Article
- Magnetic susceptibility anisotropy of myocardium imaged by cardiovascular magnetic resonance reflects the anisotropy of myocardial filament α-helix polypeptide bonds.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2015Article
- Susceptibility-weighted imaging and quantitative susceptibility mapping in the brain.Journal of magnetic resonance imaging : JMRI · 2015Review
- Quantitative susceptibility mapping (QSM): Decoding MRI data for a tissue magnetic biomarker.Magnetic resonance in medicine · 2015Review
- Prenatal alcohol exposure reduces magnetic susceptibility contrast and anisotropy in the white matter of mouse brains.NeuroImage · 2014Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
purposeMR histology based on magnetic susceptibility can be used to visualize diamagnetic myelin (and its deterioration) in the central nervous system and is facilitated by the application of high magnetic field strengths and paramagnetic contrast agents. Characterizing the effect of these tools will aid in assessing white matter myelin content and microstructure.
methodsImage data from six gadolinium-perfused mouse brain specimens were acquired at 2.0, 7.0, and 9.4 Tesla. Magnetic susceptibility contrast was analyzed for its dependence on field strength, gadolinium concentration, and white matter fiber orientation. A model for this contrast is presented based on the three-pool model for white matter.
resultsThe specimen data illustrate that white-gray matter susceptibility contrast is field strength independent. White-gray matter contrast improves significantly as a function of gadolinium contrast agent in the tissue, i.e., white matter appears increasingly more diamagnetic relative to gray matter. The simulated data from the model suggest that susceptibility anisotropy of white matter fiber bundles increases nonlinearly as a function of gadolinium concentration due to contrast agent compartmentalization into the extracellular white matter water pool.
conclusionUsing contrast agents in MR histology facilitates white-gray matter susceptibility contrast modulation and the probing of white matter microstructure and orientation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.