Evidence map›Paper›PMID 24442851›Full record

ArticleSchizophrenia bulletin2014

Partial genetic deletion of neuregulin 1 modulates the effects of stress on sensorimotor gating, dendritic morphology, and HPA axis activity in adolescent mice.

Tariq W Chohan, Aurelie A Boucher, Jarrah R Spencer, Mustafa S Kassem, Areeg A Hamdi, Tim Karl, Sandra Y Fok, Maxwell R Bennett, Jonathon C Arnold

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

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  14. Schizophrenia: a consequence of gene-environment interactions?Frontiers in behavioral neuroscience · 2014
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Tariq W ChohanThe Brain and Mind Research Institute, University of Sydney, Sydney, NSW 2006, Australia; Discipline of Pharmacology, School of Medical Science, University of Sydney, Sydney, NSW 2006, Australia;
Aurelie A BoucherThe Brain and Mind Research Institute, University of Sydney, Sydney, NSW 2006, Australia;
Jarrah R SpencerThe Brain and Mind Research Institute, University of Sydney, Sydney, NSW 2006, Australia; Discipline of Pharmacology, School of Medical Science, University of Sydney, Sydney, NSW 2006, Australia;
Mustafa S KassemThe Brain and Mind Research Institute, University of Sydney, Sydney, NSW 2006, Australia;
Areeg A HamdiDiscipline of Pharmacology, School of Medical Science, University of Sydney, Sydney, NSW 2006, Australia;
Tim KarlNeuroscience Research Australia, Randwick, NSW 2031, Australia.
Sandra Y FokThe Brain and Mind Research Institute, University of Sydney, Sydney, NSW 2006, Australia;
Maxwell R BennettThe Brain and Mind Research Institute, University of Sydney, Sydney, NSW 2006, Australia;
Jonathon C ArnoldThe Brain and Mind Research Institute, University of Sydney, Sydney, NSW 2006, Australia; Discipline of Pharmacology, School of Medical Science, University of Sydney, Sydney, NSW 2006, Australia; jonathon.arnold@sydney.edu.au.
University of Sydney · AUNeuroscience Research Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stress has been linked to the pathogenesis of schizophrenia. Genetic variation in neuregulin 1 (NRG1) increases the risk of developing schizophrenia and may help predict which high-risk individuals will transition to psychosis. NRG1 also modulates sensorimotor gating, a schizophrenia endophenotype. We used an animal model to demonstrate that partial genetic deletion of Nrg1 interacts with stress to promote neurobehavioral deficits of relevance to schizophrenia. Nrg1 heterozygous (HET) mice displayed greater acute stress-induced anxiety-related behavior than wild-type (WT) mice. Repeated stress in adolescence disrupted the normal development of higher prepulse inhibition of startle selectively in Nrg1 HET mice but not in WT mice. Further, repeated stress increased dendritic spine density in pyramidal neurons of the medial prefrontal cortex (mPFC) selectively in Nrg1 HET mice. Partial genetic deletion of Nrg1 also modulated the adaptive response of the hypothalamic-pituitary-adrenal axis to repeated stress, with Nrg1 HET displaying a reduced repeated stress-induced level of plasma corticosterone than WT mice. Our results demonstrate that Nrg1 confers vulnerability to repeated stress-induced sensorimotor gating deficits, dendritic spine growth in the mPFC, and an abberant endocrine response in adolescence.

Indexed as

Dendritic SpinesAnimalsDisease Models, AnimalFemaleHypothalamo-Hypophyseal SystemMaleMiceMice, Inbred C57BLNeuregulin-1Pituitary-Adrenal SystemPrefrontal CortexPrepulse InhibitionSensory GatingStress, PsychologicalNeuregulin-1adolescencedendritic morphologyneuregulin 1PPIschizophreniastress

Identifiers

PMID24442851
PMCPMC4193694
OpenAlexW2020688986

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.