ReviewMolecular neurobiology2014
Remote neurodegeneration: multiple actors for one play.
Review in Molecular neurobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 57 citations in OpenAlex.
- A complex network perspective on brain disease.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Cellular senescence as a key contributor to secondary neurodegeneration in traumatic brain injury and stroke.Translational neurodegeneration · 2024Review
- After 55 Years of Neurorehabilitation, What Is the Plan?Brain sciences · 2022Review
- Restoration of ER proteostasis attenuates remote apoptotic cell death after spinal cord injury by reducing autophagosome overload.Cell death & disease · 2022Article
- Human umbilical cord mesenchymal stem cells-derived extracellular vesicles facilitate the repair of spinal cord injury via the miR-29b-3p/PTEN/Akt/mTOR axis.Cell death discovery · 2021Article
- Functional Weight of Somatic and Cognitive Networks and Asymmetry of Compensatory Mechanisms: Collaboration or Divergency among Hemispheres after Cerebrovascular Accident?Life (Basel, Switzerland) · 2021Review
- The plasticity of plasticity: lesson from remote microglia induced by focal central nervous system injury.Neural regeneration research · 2020Article
- Models of Network Spread and Network Degeneration in Brain Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Review
- Resolvin D1 Halts Remote Neuroinflammation and Improves Functional Recovery after Focal Brain Damage Via ALX/FPR2 Receptor-Regulated MicroRNAs.Molecular neurobiology · 2018Article
- Inflammation and blood-brain barrier breach remote from the primary injury following neurotrauma.Journal of neuroinflammation · 2018Article
- Synaptic pathology in the cerebellar dentate nucleus in chronic multiple sclerosis.Brain pathology (Zurich, Switzerland) · 2017Article
- Autophagy Inhibition Favors Survival of Rubrospinal Neurons After Spinal Cord Hemisection.Molecular neurobiology · 2017Article
- Thalamic alterations remote to infarct appear as focal iron accumulation and impact clinical outcome.Brain : a journal of neurology · 2017Article
- Repetitive transcranial magnetic stimulation reduces remote apoptotic cell death and inflammation after focal brain injury.Journal of neuroinflammation · 2016Article
- Reducing synuclein accumulation improves neuronal survival after spinal cord injury.Experimental neurology · 2016Article
- New Insights into the Role of Oxidative Stress Mechanisms in the Pathophysiology and Treatment of Multiple Sclerosis.Oxidative medicine and cellular longevity · 2016Review
- Relating Cortical Atrophy in Temporal Lobe Epilepsy with Graph Diffusion-Based Network Models.PLoS computational biology · 2015Article
- Function and Mechanisms of Autophagy in Brain and Spinal Cord Trauma.Antioxidants & redox signaling · 2015Review
- White matter lesional predictors of chronic visual neglect: a longitudinal study.Brain : a journal of neurology · 2015Article
- Remote degeneration: insights from the hemicerebellectomy model.Cerebellum (London, England) · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Remote neurodegeneration significantly influences the clinical outcome in many central nervous system (CNS) pathologies, such as stroke, multiple sclerosis, and traumatic brain and spinal cord injuries. Because these processes develop days or months after injury, they are accompanied by a therapeutic window of opportunity. The complexity and clinical significance of remote damage is prompting many groups to examine the factors of remote degeneration. This research is providing insights into key unanswered questions, opening new avenues for innovative neuroprotective therapies. In this review, we evaluate data from various remote degeneration models to describe the complexity of the systems that are involved and the importance of their interactions in reducing damage and promoting recovery after brain lesions. Specifically, we recapitulate the current data on remote neuronal degeneration, focusing on molecular and cellular events, as studied in stroke and brain and spinal cord injury models. Remote damage is a multifactorial phenomenon in which many components become active in specific time frames. Days, weeks, or months after injury onset, the interplay between key effectors differentially affects neuronal survival and functional outcomes. In particular, we discuss apoptosis, inflammation, oxidative damage, and autophagy-all of which mediate remote degeneration at specific times. We also review current findings on the pharmacological manipulation of remote degeneration mechanisms in reducing damage and sustaining outcomes. These novel treatments differ from those that have been proposed to limit primary lesion site damage, representing new perspectives on neuroprotection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.