ArticleParasitology research2014
High diversity of human-pathogenic Enterocytozoon bieneusi genotypes in swine in northeast China.
Article in Parasitology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Global molecular epidemiology of microsporidia in pigs and wild boars with emphasis on Enterocytozoon bieneusi: A systematic review and meta-analysis.Veterinary medicine and science · 2022Pooled it
- Molecular epidemiology ofFrontiers in cellular and infection microbiology · 2026Article
- Genetic Diversity ofPathogens (Basel, Switzerland) · 2025Article
- Prevalence and genotypic identification of Cryptosporidium spp., Giardia duodenalis and Enterocytozoon bieneusi in farmed ostriches (Struthio camelus) by the Yellow River in Zhengzhou city, central China.BMC veterinary research · 2025Article
- Detection ofAnimals : an open access journal from MDPI · 2024Article
- Molecular epidemiology of Enterocytozoon bieneusi from foxes and raccoon dogs in the Henan and Hebei provinces in China.BMC veterinary research · 2024Article
- Chronic Infections in Mammals Due to Microsporidia.Experientia supplementum (2012) · 2022Article
- Prevalence and genotyping distribution ofFrontiers in microbiology · 2022Article
- Molecular Detection and Genotyping ofFrontiers in veterinary science · 2022Article
- A Perspective on the Molecular Identification, Classification, and Epidemiology of Enterocytozoon bieneusi of Animals.Experientia supplementum (2012) · 2022Article
- Ecological and public health significance ofOne health (Amsterdam, Netherlands) · 2021Review
- Molecular-Based Detection ofFrontiers in veterinary science · 2021Article
- Prevalence and new genotypes of Enterocytozoon bieneusi in sheltered dogs and cats in Sichuan province, southwestern China.Parasite (Paris, France) · 2021Article
- Molecular characterization and novel genotypes ofInternational journal for parasitology. Parasites and wildlife · 2020Article
- Occurrence, risk factors and genotypes of Enterocytozoon bieneusi in dogs and cats in Guangzhou, southern China: high genotype diversity and zoonotic concern.BMC veterinary research · 2020Article
- Molecular detection of porcine Enterocytozoon bieneusi infection in Peninsular Malaysia and epidemiological risk factors associated with potentially zoonotic genotypes.Parasitology research · 2020Article
- Occurrence and genetic characteristics of Cryptosporidium spp. and Enterocytozoon bieneusi in pet red squirrels (Sciurus vulgaris) in China.Scientific reports · 2020Article
- First detection of Enterocytozoon bieneusi in whooper swans (Cygnus cygnus) in China.Parasites & vectors · 2020Article
- Molecular detection of Enterocytozoon bieneusi in farm-raised pigs in Hainan Province, China: infection rates, genotype distributions, and zoonotic potential.Parasite (Paris, France) · 2020Article
- Prevalence and Molecular Characterization ofThe American journal of tropical medicine and hygiene · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the advances in defining Enterocytozoon bieneusi genotypes worldwide, rare genotypic surveys have been documented on this ubiquitous pathogenic protozoan in mammals in China, especially the role of pigs in zoonotic transmission of microsporidiosis remains unclear. In this study, the distribution of E. bieneusi genotypes in 113 duodenal mucosal specimens of pigs with acute diarrhea from 15 cities in northeast China was determined by PCR and DNA sequence analysis of the ribosomal internal transcribed spacer. The organism was detected in 51 (45.1%) pigs from 12 cities, with infection rates of the nursery pigs (21/33, 63.6%) significantly higher than the preweaned (25/61, 41.0%; P < 0.05) and the growing (5/19, 26.3%; P < 0.01) ones. E. bieneusi belongs to nine known human-pathogenic genotypes (D, EbpA, EbpC, EbpD, H, Henan-I, Henan-III, Henan-IV, and O) and eight new genotypes (CS-1 to CS-8). Genotypes D, EbpA, EbpC, EbpD, Henan-I, Henan-III, and Henan-IV have been found in human infections and D, EbpA, EbpC, and EbpD in wastewater in central China. The new genotypes were genetically clustered into a group of existing E. bieneusi genotypes with zoonotic potential. Considering the discovery of a high prevalence and wide genetic diversity of E. bieneusi zoonotic strains in pigs in northeast China and the co-occurrence of seven known genotypes in pigs and humans and four in pigs and wastewater, pigs probably served as a reservoir for human microsporidiosis and an important source of water contamination in China.
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