ArticleJournal of biomedical optics2014
Network signatures of nuclear and cytoplasmic density alterations in a model of pre and postmetastatic colorectal cancer.
Article in Journal of biomedical optics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
- Quantitative Analysis of Colonic Epithelial Cell Aging in a Cell-cycle like Model: Changes in Nucleus and Cytoplasm Along the Crypt Axis.Proceedings of SPIE--the International Society for Optical Engineering · 2025Article
- Hydrodynamic assisted multiparametric particle spectrometry.Scientific reports · 2021Article
- Zinc Phthalocyanine Photochemistry by Raman Imaging, Fluorescence Spectroscopy and Femtosecond Spectroscopy in Normal and Cancerous Human Colon Tissues and Single Cells.Molecules (Basel, Switzerland) · 2020Article
- Multi-ATOM: Ultrahigh-throughput single-cell quantitative phase imaging with subcellular resolution.Journal of biophotonics · 2019Article
- Biochemical fingerprint of colorectal cancer cell lines using label-free live single-cell Raman spectroscopy.Journal of Raman spectroscopy : JRS · 2018Article
- Quantitative assessment of cancer cell morphology and motility using telecentric digital holographic microscopy and machine learning.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2018Article
- Critical behavior of subcellular density organization during neutrophil activation and migration.Cellular and molecular bioengineering · 2015Article
- Effect of ionizing radiation on the physical biology of head and neck squamous cell carcinoma cells.Cellular and molecular bioengineering · 2015Article
- A physical sciences network characterization of circulating tumor cell aggregate transport.American journal of physiology. Cell physiology · 2015Article
- The thrombotic potential of circulating tumor microemboli: computational modeling of circulating tumor cell-induced coagulation.American journal of physiology. Cell physiology · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Cells contributing to the pathogenesis of cancer possess cytoplasmic and nuclear structural alterations that accompany their aberrant genetic, epigenetic, and molecular perturbations. Although it is known that architectural changes in primary and metastatic tumor cells can be quantified through variations in cellular density at the nanometer and micrometer spatial scales, the interdependent relationships among nuclear and cytoplasmic density as a function of tumorigenic potential has not been thoroughly investigated. We present a combined optical approach utilizing quantitative phase microscopy and partial wave spectroscopic microscopy to perform parallel structural characterizations of cellular architecture. Using the isogenic SW480 and SW620 cell lines as a model of pre and postmetastatic transition in colorectal cancer, we demonstrate that nuclear and cytoplasmic nanoscale disorder, micron-scale dry mass content, mean dry mass density, and shape metrics of the dry mass density histogram are uniquely correlated within and across different cellular compartments for a given cell type. The correlations of these physical parameters can be interpreted as networks whose nodal importance and level of connection independence differ according to disease stage. This work demonstrates how optically derived biophysical parameters are linked within and across different cellular compartments during the architectural orchestration of the metastatic phenotype.
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