ArticleNature neuroscience2014
Imaging an optogenetic pH sensor reveals that protons mediate lateral inhibition in the retina.
Article in Nature neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
56 citing papers in PubMed, 88 citations in OpenAlex.
- Role of the C-terminal domain in modifying pH-dependent regulation of CaChannels (Austin, Tex.) · 2025Article
- The Role of the CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- ASIC currents in cultured primate retinal amacrine/ganglion cells.Physiological reports · 2025Article
- The sodium-bicarbonate cotransporter Slc4a5 mediates feedback at the first synapse of vision.Neuron · 2024Article
- Presynaptic Proteins and Their Roles in Visual Processing by the Retina.Annual review of vision science · 2024Review
- Adaptative machine vision with microsecond-level accurate perception beyond human retina.Nature communications · 2024Article
- Mechanisms of simultaneous linear and nonlinear computations at the mammalian cone photoreceptor synapse.Nature communications · 2023Article
- Tandem pore domain acid-sensitive K channel 3 (TASK-3) regulates visual sensitivity in healthy and aging retina.Science advances · 2022Article
- Computational modeling predicts ephemeral acidic microdomains in the glutamatergic synaptic cleft.Biophysical journal · 2021Article
- A multiscale continuum model of the vertebrate outer retina: The temporal dynamics of background-induced flicker enhancement.Journal of theoretical biology · 2021Article
- Transmission at rod and cone ribbon synapses in the retina.Pflugers Archiv : European journal of physiology · 2021Review
- Extracellular Protons Mediate Presynaptic Homeostatic Potentiation at the Mouse Neuromuscular Junction.Neuroscience · 2021Article
- Synaptic Scaffolds, Ion Channels and Polyamines in Mouse Photoreceptor Synapses: Anatomy of a Signaling Complex.Frontiers in cellular neuroscience · 2021Article
- Review and Hypothesis: A Potential Common Link Between Glial Cells, Calcium Changes, Modulation of Synaptic Transmission, Spreading Depression, Migraine, and Epilepsy-HFrontiers in cellular neuroscience · 2021Article
- Extracellular ATP-Induced Alterations in Extracellular HFrontiers in cellular neuroscience · 2021Article
- A new tool to sense pH changes at the neuromuscular junction synaptic cleft.Scientific reports · 2020Article
- Alkalinization of the Synaptic Cleft during Excitatory Neurotransmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Molecular mechanisms underlying selective synapse formation of vertebrate retinal photoreceptor cells.Cellular and molecular life sciences : CMLS · 2020Review
- Neuronal Glutamatergic Synaptic Clefts Alkalinize Rather Than Acidify during Neurotransmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Horizontal Cell Feedback to Cone Photoreceptors in Mammalian Retina: Novel Insights From the GABA-pH Hybrid Model.Frontiers in cellular neuroscience · 2020Review
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3 authors at 1 institution in 1 country.
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Abstract
The reciprocal synapse between photoreceptors and horizontal cells underlies lateral inhibition and establishes the antagonistic center-surround receptive fields of retinal neurons to enhance visual contrast. Despite decades of study, the signal mediating the negative feedback from horizontal cells to cones has remained under debate because the small, invaginated synaptic cleft has precluded measurement. Using zebrafish retinas, we show that light elicits a change in synaptic proton concentration with the correct magnitude, kinetics and spatial dependence to account for lateral inhibition. Light, which hyperpolarizes horizontal cells, causes synaptic alkalinization, whereas activating an exogenously expressed ligand-gated Na(+) channel, which depolarizes horizontal cells, causes synaptic acidification. Whereas acidification was prevented by blocking a proton pump, re-alkalinization was prevented by blocking proton-permeant ion channels, suggesting that distinct mechanisms underlie proton efflux and influx. These findings reveal that protons mediate lateral inhibition in the retina, raising the possibility that protons are unrecognized retrograde messengers elsewhere in the nervous system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.