ArticleAmerican journal of physiology. Heart and circulatory physiology2014
β-Adrenergic blockade enhances coronary vasoconstrictor response to forehead cooling.
Article in American journal of physiology. Heart and circulatory physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 12 citations in OpenAlex.
- Beta-1 vs. beta-2 adrenergic control of coronary blood flow during isometric handgrip exercise in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- Esmolol infusion versus propranolol infusion: effects on heart rate and blood pressure in healthy volunteers.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- Temperature-Dependent Modulation of the QRS Axis Following Water Intake in Healthy Adults: A Cross-Sectional Study.Health science reports · 2026Article
- Effects of alpha-adrenergic receptor blockade on coronary circulation in postmenopausal women.European journal of applied physiology · 2023Article
- Sympathetic control of the coronary circulation during trigeminal nerve stimulation in humans.European journal of applied physiology · 2023Article
- Sympathetic and sensory nerve fiber function in multiple system atrophy and idiopathic Parkinson's disease.Journal of neurology · 2021Article
- Reduced central sympathetic activity in Parkinson's disease.Brain and behavior · 2019Article
- Difference in the integrated effects of sympathetic vasoconstriction and local vasodilation in human skeletal muscle and skin microvasculature.Physiological reports · 2019Article
- Coronary Exercise Hyperemia Is Impaired in Patients with Peripheral Arterial Disease.Annals of vascular surgery · 2017Article
- Effect of adrenergic agonists on coronary blood flow: a laboratory study in healthy volunteers.Physiological reports · 2016Article
- β-Adrenergic receptor blockade impairs coronary exercise hyperemia in young men but not older men.American journal of physiology. Heart and circulatory physiology · 2014Article
- Coronary responses to cold air inhalation following afferent and efferent blockade.American journal of physiology. Heart and circulatory physiology · 2014Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Forehead cooling activates the sympathetic nervous system and can trigger angina pectoris in susceptible individuals. However, the effect of forehead cooling on coronary blood flow velocity (CBV) is not well understood. In this human experiment, we tested the hypotheses that forehead cooling reduces CBV (i.e., coronary vasoconstriction) and that this vasoconstrictor effect would be enhanced under systemic β-adrenergic blockade. A total of 30 healthy subjects (age range, 23-79 years) underwent Doppler echocardiography evaluation of CBV in response to 60 s of forehead cooling (1°C ice bag on forehead). A subset of subjects (n = 10) also underwent the procedures after an intravenous infusion of propranolol. Rate pressure product (RPP) was used as an index of myocardial oxygen demand. Consistent with our first hypothesis, forehead cooling reduced CBV from 19.5 ± 0.7 to 17.5 ± 0.8 cm/s (P < 0.001), whereas mean arterial pressure increased by 11 ± 2 mmHg (P < 0.001). Consistent with our second hypothesis, forehead cooling reduced CBV under propranolol despite a significant rise in RPP. The current studies indicate that forehead cooling elicits a sympathetically mediated pressor response and a reduction in CBV, and this effect is augmented under β-blockade. The results are consistent with sympathetic activation of β-receptor coronary vasodilation in humans, as has been demonstrated in animals.
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