Evidence map›Paper›PMID 24441097›Full record

ArticleThe Journal of investigative dermatology2014

Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms.

Bingshan Li, Lam C Tsoi, William R Swindell, Johann E Gudjonsson, Trilokraj Tejasvi, Andrew Johnston, Jun Ding, Philip E Stuart, Xianying Xing, James J Kochkodan and 5 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03662685 (Immunogenetic Profiling of Goeckerman Therapy in the Treatment of Psoriasis Vulgaris), which is not on this map. Cited by 219 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
219citing papers in PubMed, 8 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03662685 phase1terminatednot on this mapstarted 2018, after this paper: background citation

Immunogenetic Profiling of Goeckerman Therapy in the Treatment of Psoriasis Vulgaris

TypeinterventionalSponsorUniversity of California, San FranciscoRan2018 to 2024Enrolled4ConditionsPsoriasis Vulgaris, PsoriasisArmsGoeckerman Therapy, Crude Coal Tar Only, Phototherapy Only
3 · Its place in the literature

Who cites it

219 citing papers in PubMed, 8 syntheses or guidelines pooled it, 400 citations in OpenAlex.

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  19. Exploration of shared gene signatures and molecular mechanisms between psoriasis and COVID-19: evidence from transcriptome data.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Article
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159 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Bingshan LiDepartment of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, USA; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
Lam C TsoiDepartment of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
William R SwindellDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
Johann E GudjonssonDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
Trilokraj TejasviDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA; Ann Arbor Veterans Affairs Hospital, University of Michigan, Ann Arbor, Michigan, USA.
Andrew JohnstonDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
Jun DingDepartment of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA; Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Philip E StuartDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
Xianying XingDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
James J KochkodanDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
John J VoorheesDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
Hyun M KangDepartment of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
Rajan P NairDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
Goncalo R AbecasisDepartment of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA. Electronic address: goncalo@umich.edu.
James T ElderDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA; Ann Arbor Veterans Affairs Hospital, University of Michigan, Ann Arbor, Michigan, USA. Electronic address: jelder@umich.edu.
University of Michigan–Ann Arbor · USCenter for Human Genetics · US

Funding

Linkage analysis of familial psoriasis(Supplement)R01AR042742 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 1994 to 2021
$10.1M
Genetic and Genomic Dissection of Psoriatic ArthritisR01AR063611 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD, GLADMAN, DAFNA D · 2012 to 2023
$6.2M
Identification of Psoriatic Arthritis Genes in the MHCR01AR050511 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2004 to 2013
$4.2M
Combined Analysis of Gene Expression and DNA Variation in PsoriasisR01AR054966 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2007 to 2011
$3.2M
Functional Genomics of PsoriasisR01AR065183 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2013 to 2016
$1.7M
Role of the Psoriasis Associated IL23R Risk Variants on Th17 Biology and FunctionK08AR060802 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GUDJONSSON, JOHANN ELI · 2011 to 2015
$636k
Biologic Activities of IL-36 Cytokines in PsoriasisK01AR064765 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JOHNSTON, ANDREW · 2013 to 2017
$506k
NIAMS NIH HHS AR054966NIAMS NIH HHS K01 AR064765NIAMS NIH HHS K01 AR064765-01NIAMS NIH HHS K08 AR060802NIAMS NIH HHS R01 AR042742NIAMS NIH HHS R01 AR050511NIAMS NIH HHS R01 AR054966NIAMS NIH HHS R01 AR063611NIAMS NIH HHS R01 AR065183
6 · The paper itself

Abstract

To increase our understanding of psoriasis, we used high-throughput complementary DNA sequencing (RNA-seq) to assay the transcriptomes of lesional psoriatic and normal skin. We sequenced polyadenylated RNA-derived complementary DNAs from 92 psoriatic and 82 normal punch biopsies, generating an average of ∼38 million single-end 80-bp reads per sample. Comparison of 42 samples examined by both RNA-seq and microarray revealed marked differences in sensitivity, with transcripts identified only by RNA-seq having much lower expression than those also identified by microarray. RNA-seq identified many more differentially expressed transcripts enriched in immune system processes. Weighted gene coexpression network analysis (WGCNA) revealed multiple modules of coordinately expressed epidermal differentiation genes, overlapping significantly with genes regulated by the long noncoding RNA TINCR, its target gene, staufen-1 (STAU1), the p63 target gene ZNF750, and its target KLF4. Other coordinately expressed modules were enriched for lymphoid and/or myeloid signature transcripts and genes induced by IL-17 in keratinocytes. Dermally expressed genes were significantly downregulated in psoriatic biopsies, most likely because of expansion of the epidermal compartment. These results show the power of WGCNA to elucidate gene regulatory circuits in psoriasis, and emphasize the influence of tissue architecture in both differential expression and coexpression analysis.

Indexed as

Case-Control StudiesCytoskeletal ProteinsDown-RegulationEpidermisGene Expression ProfilingHigh-Throughput Nucleotide SequencingHumansInterleukin-17KeratinocytesKruppel-Like Factor 4Kruppel-Like Transcription FactorsOligonucleotide Array Sequence AnalysisPsoriasisRNA-Binding ProteinsRNA, Long NoncodingTranscription FactorsCytoskeletal ProteinsInterleukin-17KLF4 protein, humanKruppel-Like Factor 4Kruppel-Like Transcription FactorsRNA-Binding ProteinsRNA, Long NoncodingSTAU1 protein, humanTranscription FactorsTumor Suppressor ProteinsZNF750 protein, human

Identifiers

PMID24441097
PMCPMC4057954
OpenAlexW2094792719

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.