ArticleInternational journal of obesity (2005)2014
Breath carbon stable isotope ratios identify changes in energy balance and substrate utilization in humans.
Article in International journal of obesity (2005), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- The Breath Carbon Isotope Ratio Reflects Short-term Added-Sugar Intake in a Dose-Response, Crossover Feeding Study of 12 Healthy Adults.The Journal of nutrition · 2021Trial
- Article
- Comb spectroscopy of COBiomedical optics express · 2024Article
- Overview of Breath Testing in Clinical Practice in North America.JPGN reports · 2021Review
- Article
- Nutrition Therapy in Sepsis.Critical care clinics · 2018Review
- Tailoring nutrition therapy to illness and recovery.Critical care (London, England) · 2017Review
- Muscle mass and physical recovery in ICU: innovations for targeting of nutrition and exercise.Current opinion in critical care · 2017Article
- Stable isotope biomarker breath tests for human metabolic and infectious diseases: a review of recent patent literature.Expert opinion on therapeutic patents · 2016Review
- (13)C-Breath testing in animals: theory, applications, and future directions.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Review
- NMR Metabolomics Show Evidence for Mitochondrial Oxidative Stress in a Mouse Model of Polycystic Ovary Syndrome.Journal of proteome research · 2015Article
- Stable Isotope Ratios as Biomarkers of Diet for Health Research.Annual review of nutrition · 2015Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid detection of shifts in substrate utilization and energy balance would provide a compelling biofeedback tool for individuals attempting weight loss. As a proof of concept, we tested whether the natural abundance of exhaled carbon stable isotope ratios (breath δ(13)C) reflects shifts between negative and positive energy balance. Volunteers (n=5) consumed a 40% energy-restricted diet for 6 days followed by 50% excess on day 7. Breath was sampled immediately before and 1 h and 2 h after breakfast, lunch and dinner. Exhaled breath δ(13)C values were measured by cavity ring-down spectroscopy. Using repeated measures analysis of variance (ANOVA) followed by Dunnett's contrasts, pre-breakfast breath values on days 2-6 were compared with day 1, and postprandial day 7 time points were compared with pre-breakfast day 7. Energy restriction diminished pre-breakfast breath δ(13)C by day 3 (P<0.05). On day 7, increased energy intake was first detected immediately before dinner (-23.8±0.6 vs -21.9±0.7‰, P=0.002 (means±s.d.)), and breath δ(13)C remained elevated at least 2 h post dinner. In conclusion, when shifting between negative and positive energy balance, breath δ(13)C showed anticipated isotopic changes. Although additional research is needed to determine specificity and repeatability, this method may provide a biomarker for marked increases in caloric intake.
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