Evidence map›Paper›PMID 24440706›Full record

ArticleBiochemical and biophysical research communications2014

Thyroid hormone status regulates the expression of secretory phospholipases.

Pragya Sharma, Tania Levesque, Eric Boilard, Edwards A Park

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Secretory phospholipase AJournal of lipid research · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Pragya SharmaDepartment of Pharmacology, College of Medicine, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, United States.
Tania LevesqueDepartment of Infectious Diseases and Immunity, Faculté de Médecine de l'Université Laval, CHUQ Research Center and Division of Rheumatology, CHUQ, Quebec City, QC G1V 4G2, Canada.
Eric BoilardDepartment of Infectious Diseases and Immunity, Faculté de Médecine de l'Université Laval, CHUQ Research Center and Division of Rheumatology, CHUQ, Quebec City, QC G1V 4G2, Canada.
Edwards A ParkDepartment of Pharmacology, College of Medicine, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, United States. Electronic address: epark@uthsc.edu.
Université Laval · CAUniversity of Tennessee Health Science Center · US

Funding

Regulation of metabolic gene expressionR01DK059368 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI PARK, EDWARDS A · 2003 to 2011
$2.1M
CIHRNIDDK NIH HHS R01 DK059368NIDDK NIH HHS R01DK059368
6 · The paper itself

Abstract

Thyroid hormone (T3) stimulates various metabolic pathways and the hepatic actions of T3 are mediated primarily through the thyroid hormone receptor beta (TRβ). Hypothyroidism has been linked with low grade inflammation, elevated risk of hepatic steatosis and atherosclerosis. Secretory phospholipases (sPLA2) are associated with inflammation, hyperlipidemia and atherosclerosis. Due to potential linkage between thyroid hormone and sPLA2, we investigated the effect of thyroid hormone status on the regulation of secretory phospholipases in mice, rats and human liver. T3 suppressed the expression of the sPLA2 group IIa (PLA2g2a) gene in the liver of BALB/c mice and C57BL/6 transgenic mice expressing the human PLA2g2a. PLA2g2a was elevated with hypothyroidism and high fat diets which may contribute to the low grade inflammation associated with hypothyroidism and diet induced obesity. We also examined the effects of the TRβ agonist eprotirome on hepatic gene regulation. We observed that eprotirome inhibited the expression of selected sPLA2 genes and furthermore the cytokine mediated induction PLA2g2a was suppressed. In addition, eprotirome induced genes involved in fatty acid oxidation and cholesterol clearance while inhibiting lipogenic genes. Our results indicate that in vivo thyroid hormone status regulates the abundance of sPLA2 and the inhibition of PLA2g2a by T3 is conserved across species. By regulating sPLA2 genes, T3 may impact processes associated with atherosclerosis and inflammation and TRβ agonists may ameliorate inflammation and hyperlipidemia.

Indexed as

AnilidesAnimalsGene Expression Regulation, EnzymologicGroup II Phospholipases A2HepatocytesHep G2 CellsHumansHyperlipidemiasHyperthyroidismHypothyroidismInflammationMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, Transgenic3-((3,5-dibromo-4-(4-hydroxy-3-(1-methylethyl)phenoxy)phenyl)amino)-3-oxopropanoic acidAnilidesGroup II Phospholipases A2Phospholipases A2, SecretoryPLA2G2A protein, humanPla2g2a protein, mousePla2g2a protein, ratRNA, MessengerThyroid Hormone Receptors betaTriiodothyronineEprotiromePLA2g2aSecretory phospholipase A2Thyroid hormone

Identifiers

PMID24440706
PMCPMC4687730
OpenAlexW1995965386

What OpenQuestion holds

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LicenceTDM
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.