ArticlePathophysiology : the official journal of the International Society for Pathophysiology2014
Commensal and probiotic bacteria may prevent NEC by maturing intestinal host defenses.
Article in Pathophysiology : the official journal of the International Society for Pathophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- The impact of probiotic supplementation during pregnancy on DNA methylation of obesity-related genes in mothers and their children.European journal of nutrition · 2019Trial
- Changes in intestinal bacterial characteristics during hospitalization in the NICU in very low birth weight infants.Italian journal of pediatrics · 2025Article
- The Complex Link and Disease Between the Gut Microbiome and the Immune System in Infants.Frontiers in cellular and infection microbiology · 2022Review
- Review of claudin proteins as potential biomarkers for necrotizing enterocolitis.Irish journal of medical science · 2021Review
- The Association between Early-Life Gut Microbiota and Long-Term Health and Diseases.Journal of clinical medicine · 2021Review
- Preventive Effect of Bifidobacterium Supplementation on Neonatal Cholestasis in Preterm Neonates with Very Low Birth Weight.Gastroenterology research and practice · 2020Article
- Bacteroides fragilis Strain ZY-312 Defense against Cronobacter sakazakii-Induced Necrotizing EnterocolitismSystems · 2019Article
- To start or not: Factors to consider when implementing routine probiotic use in the NICU.Early human development · 2019Review
- Effects of lactoferrin on neonatal pathogens and Bifidobacterium breve in human breast milk.PloS one · 2018Article
- Effect of Bacillus subtilis on Aeromonas hydrophila-induced intestinal mucosal barrier function damage and inflammation in grass carp (Ctenopharyngodon idella).Scientific reports · 2017Article
- Lactobacillus rhamnosus GG supernatant enhance neonatal resistance to systemic Escherichia coli K1 infection by accelerating development of intestinal defense.Scientific reports · 2017Article
- Probiotic Mixture Golden Bifido Prevents NeonatalFrontiers in microbiology · 2017Article
- Temporal bacterial and metabolic development of the preterm gut reveals specific signatures in health and disease.Microbiome · 2016Article
- Survey and evidence based review of probiotics used in very low birth weight preterm infants within the United States.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- [Research progress of the application of probiotics in preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Review
- Microorganisms with claimed probiotic properties: an overview of recent literature.International journal of environmental research and public health · 2014Review
- Review
- The intestinal microbiome in early life: health and disease.Frontiers in immunology · 2014Review
- New insight into an old concept: role of immature erythroid cells in immune pathogenesis of neonatal infection.Frontiers in immunology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Necrotizing enterocolitis (NEC) is a devastating disease of prematurity with significant morbidity and mortality. Immaturity of intestinal host defenses predisposes the premature infant gut to injury. An abnormal bacterial colonization pattern with a deficiency of commensal bacteria may lead to a further breakdown of these host defense mechanisms, predisposing the infant to NEC. The presence of probiotic and commensal bacteria within the gut has been shown to mature the intestinal defense system through a variety of mechanisms. We have shown that commensal and probiotic bacteria can promote intestinal host defenses by reducing apoptotic signaling, blocking inflammatory signaling, and maturing barrier function in immature intestinal epithelia. Future studies aimed at elucidating the mechanisms by which probiotic and commensal bacteria exert their effects will be critical to developing effective preventive therapies for NEC.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.