ReviewJournal of dentistry2014
A review of the bioactivity of hydraulic calcium silicate cements.
Review in Journal of dentistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 186 citations in OpenAlex.
- [Bioactivity of multi-matrix bioceramic root canal sealer: AnBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026Article
- An Updated Classification of Hydraulic Cements Used in Dentistry.International endodontic journal · 2026Review
- Effect of n-Butyl Cyanoacrylate Coating on the Microhardness of MM-MTA After Exposure to Moisture and Human Blood.Journal of functional biomaterials · 2026Article
- Physicochemical stability of contemporary endodontic sealers with distinct chemical bases under thermal stress: a multi-analytical approach.Odontology · 2026Article
- Wnt/β-Catenin Pathway and Hydraulic Calcium Silicate-Based Cements: A Narrative Review.Dentistry journal · 2026Review
- Biological Effects of Bioactive Glass-Containing Self-Adhesive Resin Cements on Dental Pulp Stem Cells.Journal of functional biomaterials · 2026Article
- Characteristics and Physical Properties of Indonesian Stingless Bee (International journal of dentistry · 2026Article
- Article
- A scientometric, visualization, and content analysis on surgical endodontics from inception to 2023.Odontology · 2026Review
- Bioactivity and biocompatibility of bioceramic-based pulp capping materials in laboratory and animal models.Journal of materials science. Materials in medicine · 2025Article
- Studying How Calcium Silicate and Radiopacifier Proportions Affect the Physicochemical Properties of Endodontic Calcium Silicate-Based Sealers.Materials (Basel, Switzerland) · 2025Article
- Biocompatibility of Hydraulic Calcium Silicate-Based Cement MTA FlowJournal of functional biomaterials · 2025Article
- Effect of conditioning and 3-year aging on the bond strength and interfacial morphology of glass-ionomer cement bonded to dentin.Journal of dental sciences · 2025Article
- Evaluation of Microhardness and Compressive Strength of Mineral Trioxide Aggregate Modified by Addition of Short Glass Fibers and Shredded Polyglycolic Acid Sutures.Materials (Basel, Switzerland) · 2025Article
- An Evaluation of the Biocompatibility and Chemical Properties of Two Bioceramic Root Canal Sealers in a Sealer Extrusion Model of Rat Molars.Journal of functional biomaterials · 2025Article
- In vitro evaluation of the impact of a bioceramic root canal sealer on the mechanical properties of tooth roots.Journal of dental sciences · 2024Article
- Bioactive potential of Bio-C Temp demonstrated by systemic mineralization markers and immunoexpression of bone proteins in the rat connective tissue.Journal of materials science. Materials in medicine · 2024Article
- Advances and challenges in regenerative dentistry: A systematic review of calcium phosphate and silicate-based materials on human dental pulp stem cells.Materials today. Bio · 2023Review
- Guttapercha Improves In Vitro Bioactivity and Dentin Remineralization Ability of a Bioglass Containing Polydimethylsiloxane-Based Root Canal Sealer.Molecules (Basel, Switzerland) · 2023Article
- Biomineralization ability of an experimental bioceramic endodontic sealer based on nanoparticles of calcium silicates.Medicine and pharmacy reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
Abstract
objectivesIn tissue regeneration research, the term "bioactivity" was initially used to describe the resistance to removal of a biomaterial from host tissues after intraosseous implantation. Hydraulic calcium silicate cements (HCSCs) are putatively accepted as bioactive materials, as exemplified by the increasing number of publications reporting that these cements produce an apatite-rich surface layer after they contact simulated body fluids.
methodsIn this review, the same definitions employed for establishing in vitro and in vivo bioactivity in glass-ceramics, and the proposed mechanisms involved in these phenomena are used as blueprints for investigating whether HCSCs are bioactive.
resultsThe literature abounds with evidence that HCSCs exhibit in vitro bioactivity; however, there is a general lack of stringent methodologies for characterizing the calcium phosphate phases precipitated on HCSCs. Although in vivo bioactivity has been demonstrated for some HCSCs, a fibrous connective tissue layer is frequently identified along the bone-cement interface that is reminiscent of the responses observed in bioinert materials, without accompanying clarifications to account for such observations.
conclusionsAs bone-bonding is not predictably achieved, there is insufficient scientific evidence to substantiate that HCSCs are indeed bioactive. Objective appraisal criteria should be developed for more accurately defining the bioactivity profiles of HCSCs designed for clinical use.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.