ArticleCurrent biology : CB2014
Male-specific fruitless isoforms target neurodevelopmental genes to specify a sexually dimorphic nervous system.
Article in Current biology : CB, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed, 114 citations in OpenAlex.
- Sex of central neurons controls intestinal niche signalling to drive sex differences in stem cell activity and cancer susceptibility.Nature communications · 2026Article
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- Fruitless produces diverse neuronal sex differences by editing lineage-programmed chromatin landscapes.bioRxiv : the preprint server for biology · 2026Article
- Differential neuronal survival defines a novel axis of sexual dimorphism in the Drosophila brain.Cell genomics · 2026Article
- Butterfly brains change in morphology and in gene splicing patterns after brief pheromone exposure.BMC biology · 2026Article
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- Sexual dimorphism in the complete connectome of thebioRxiv : the preprint server for biology · 2025Article
- A single-nucleus transcriptomic atlas of the adultbioRxiv : the preprint server for biology · 2025Article
- Contribution of neurons that expressiScience · 2025Article
- Lagging Brain Gene Expression Patterns of Drosophila melanogaster Young Adult Males Confound Comparisons Between Sexes.Molecular neurobiology · 2025Article
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- Neuronal identity control at the resolution of a single transcription factor isoform.bioRxiv : the preprint server for biology · 2024Article
- Genetic Coupling of Mate Recognition Systems in the Genomic Era.Cold Spring Harbor perspectives in biology · 2024Review
- Activin is a neural inducer of a male-specific muscle in Drosophila.Scientific reports · 2024Article
- A modular circuit architecture coordinates the diversification of courtship strategies inbioRxiv : the preprint server for biology · 2023Article
- Article
- Social experience and pheromone receptor activity reprogram gene expression in sensory neurons.G3 (Bethesda, Md.) · 2023Article
- Single-cell transcriptome profiles ofeLife · 2023Article
- Molecular and cellular origins of behavioral sex differences: a tiny little fly tells a lot.Frontiers in molecular neuroscience · 2023Review
- TheProceedings. Biological sciences · 2022Article
8 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundIn Drosophila, male courtship behavior is regulated in large part by the gene fruitless (fru). fru encodes a set of putative transcription factors that promote male sexual behavior by controlling the development of sexually dimorphic neuronal circuitry. Little is known about how Fru proteins function at the level of transcriptional regulation or the role that isoform diversity plays in the formation of a male-specific nervous system.
resultsTo characterize the roles of sex-specific Fru isoforms in specifying male behavior, we generated novel isoform-specific mutants and used a genomic approach to identify direct Fru isoform targets during development. We demonstrate that all Fru isoforms directly target genes involved in the development of the nervous system, with individual isoforms exhibiting unique binding specificities. We observe that fru behavioral phenotypes are specified by either a single isoform or a combination of isoforms. Finally, we illustrate the utility of these data for the identification of novel sexually dimorphic genomic enhancers and novel downstream regulators of male sexual behavior.
conclusionsThese findings suggest that Fru isoform diversity facilitates both redundancy and specificity in gene expression, and that the regulation of neuronal developmental genes may be the most ancient and conserved role of fru in the specification of a male-specific nervous system.
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