Evidence map›Paper›PMID 24440348›Full record

ReviewFEBS letters2014

Gap junction regulation by calmodulin.

Juan Zou, Mani Salarian, Yanyi Chen, Richard Veenstra, Charles F Louis, Jenny J Yang

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in FEBS letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 60 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Intracellular CaBiologia futura · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Calmodulin: a highly conserved and ubiquitous CaProceedings of the Japan Academy. Series B, Physical and biological sciences · 2024
    Review
  9. CaInternational journal of molecular sciences · 2023
    Article
  10. CaFrontiers in cellular neuroscience · 2023
    Article
  11. Anesthetics and Cell-Cell Communication: Potential CaInternational journal of molecular sciences · 2022
    Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Structural Aspects and Prediction of Calmodulin-Binding Proteins.International journal of molecular sciences · 2020
    Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Juan ZouDepartment of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, United States.
Mani SalarianDepartment of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, United States.
Yanyi ChenDepartment of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, United States.
Richard VeenstraDepartment of Pharmacology, SUNY Upstate Medical University, Syracuse, NY 13210, United States.
Charles F LouisDepartment of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, United States. Electronic address: charles.louis@ucr.edu.
Jenny J YangDepartment of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, United States. Electronic address: jenny@gsu.edu.
Georgia State University · USSUNY Upstate Medical University · USUniversity of California, Riverside · US

Funding

Designing Magnetic Resonance Protein-based Contrast Agents with High RelaxivityR01EB007268 · NIBIB · GEORGIA STATE UNIVERSITY · PI YANG, JENNY J. · 2007 to 2015
$3.1M
GAP JUNCTIONS AND IONIC CURRENTS IN DEVELOPING HEARTR01HL042220 · NHLBI · UPSTATE MEDICAL UNIVERSITY · PI VEENSTRA, RICHARD DAVID, YANG, JENNY J. · 1988 to 2013
$3.1M
Regulation of lens connexinsR01EY005684 · NEI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LOUIS, CHARLES F · 1985 to 2007
$1.7M
Structural Biology of receptor-mediated extracellular calcium signalingR01GM081749 · NIGMS · GEORGIA STATE UNIVERSITY · PI YANG, JENNY J. · 2007 to 2011
$1.2M
NEI NIH HHS EY-05684NEI NIH HHS R01 EY005684NHLBI NIH HHS HL-042220NHLBI NIH HHS R01 HL042220NIBIB NIH HHS R01 EB007268NIGMS NIH HHS GM-081749NIGMS NIH HHS R01 GM081749
6 · The paper itself

Abstract

Intracellular Ca(2+) activated calmodulin (CaM) inhibits gap junction channels in the low nanomolar to high micromolar range of [Ca(2+)]i. This regulation plays an essential role in numerous cellular processes that include hearing, lens transparency, and synchronized contractions of the heart. Previous studies have indicated that gap junction mediated cell-to-cell communication was inhibited by CaM antagonists. More recent evidence indicates a direct role of CaM in regulating several members of the connexin family. Since the intracellular loop and carboxyl termini of connexins are largely "invisible" in electron microscopy and X-ray crystallographic structures due to disorder in these domains, peptide models encompassing the putative CaM binding sites of several intracellular domains of connexins have been used to identify the Ca(2+)-dependent CaM binding sites of these proteins. This approach has been used to determine the CaM binding affinities of peptides derived from a number of different connexin-subfamilies.

Indexed as

Amino Acid SequenceAnimalsBinding SitesCalciumCalmodulinConnexinsHumansMolecular Dynamics SimulationMolecular Sequence DataProtein BindingCalciumCalmodulinConnexinsCa(2+)Calmodulin bindingConnexinGap junction regulation

Identifiers

PMID24440348
PMCPMC3989380
OpenAlexW2078998148

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.