Evidence map›Paper›PMID 24440052›Full record

ArticleHormones and behavior2014

New knockout model confirms a role for androgen receptors in regulating anxiety-like behaviors and HPA response in mice.

Chieh V Chen, Jennifer L Brummet, Joseph S Lonstein, Cynthia L Jordan, S Marc Breedlove

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hormones and behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chieh V ChenMichigan State University, Psychology Department, 293 Farm Lane, Giltner Room 108, East Lansing, MI 48824, USA. Electronic address: chieh.07@gmail.com.
Jennifer L BrummetMichigan State University, Psychology Department, 293 Farm Lane, Giltner Room 108, East Lansing, MI 48824, USA.
Joseph S LonsteinMichigan State University, Psychology Department, 293 Farm Lane, Giltner Room 108, East Lansing, MI 48824, USA; Michigan State University, Neuroscience Program, 293 Farm Lane, Giltner Room 108, East Lansing, MI 48824, USA.
Cynthia L JordanMichigan State University, Psychology Department, 293 Farm Lane, Giltner Room 108, East Lansing, MI 48824, USA; Michigan State University, Neuroscience Program, 293 Farm Lane, Giltner Room 108, East Lansing, MI 48824, USA.
S Marc BreedloveMichigan State University, Psychology Department, 293 Farm Lane, Giltner Room 108, East Lansing, MI 48824, USA; Michigan State University, Neuroscience Program, 293 Farm Lane, Giltner Room 108, East Lansing, MI 48824, USA.
Michigan State University · US

Funding

Androgen Targets in a Simple Behavioral SystemR01NS045195 · NINDS · MICHIGAN STATE UNIVERSITY · PI JORDAN, CYNTHIA L · 2003 to 2019
$5.3M
HORMONAL EFFECTS ON BEHAVIOR &SPINAL CORD MORPHOLOGYR01NS028421 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BREEDLOVE, S MARC · 1990 to 2015
$3.8M
Steroid Hormone Regulation of Anxiety-Related BehaviorsR21MH104780 · NIMH · MICHIGAN STATE UNIVERSITY · PI BREEDLOVE, S MARC · 2015 to 2016
$409k
NIMH NIH HHS R21 MH104780NINDS NIH HHS R01 NS028421NINDS NIH HHS R01 NS045195
6 · The paper itself

Abstract

Men are less likely than women to suffer from anxiety disorders. Because gonadal hormones play a crucial role in many behavioral sex differences, they may underlie sex differences in human anxiety. In rodents, testosterone (T) exerts anxiolytic effects via the androgen receptor (AR): we found that male mice with a naturally-occurring mutation rendering the AR dysfunctional, referred to as spontaneous testicular feminization mutation (sTfm), showed more anxiety-like behaviors than wildtype (WT) males. Here, we used Cre-lox recombination technology to create another dysfunctional allele for AR. These induced Tfm (iTfm) animals also displayed more anxiety-like behaviors than WTs. We further found that AR-modulation of these behaviors interacts with circadian phase. When tested in the resting phase, iTfms appeared more anxious than WTs in the open field, novel object and elevated plus maze tests, but not the light/dark box. However, when tested during the active phase (lights off), iTfms showed more anxiety-related behavior than WTs in all four tests. Finally, we confirmed a role of T acting via AR in regulating HPA axis activity, as WT males with T showed a lower baseline and overall corticosterone response, and a faster return to baseline following mild stress than did WT males without T or iTfms. These findings demonstrate that this recombined AR allele is a valuable model for studying androgenic modulation of anxiety, that the anxiolytic effects of AR in mice are more prominent in the active phase, and that HPA axis modulation by T is AR dependent.

Indexed as

Models, AnimalAndrogen-Insensitivity SyndromeAnimalsAnxietyBehavior, AnimalCorticosteroneDisease Models, AnimalFemaleHypothalamo-Hypophyseal SystemMaleMiceMice, Inbred C57BLMice, KnockoutPhotoperiodPituitary-Adrenal SystemReceptors, AndrogenCorticosteroneReceptors, AndrogenTestosteroneAndrogen insensitivityAndrogen receptorAnxietyCorticosteroneCre–lox technologyHPA axisPhotoperiodTestosterone

Identifiers

PMID24440052
PMCPMC4295784
OpenAlexW2111605462

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.