ArticleNeurobiology of aging2014
Testing the calcium hypothesis of aging in the rat hippocampus in vivo using manganese-enhanced MRI.
Article in Neurobiology of aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Longitudinal manganese-enhanced magnetic resonance imaging of neural projections and activity.NMR in biomedicine · 2022Review
- A hierarchy of manganese competition and entry in organotypic hippocampal slice cultures.NMR in biomedicine · 2021Article
- Tinnitus and temporary hearing loss result in differential noise-induced spatial reorganization of brain activity.Brain structure & function · 2018Article
- Development of manganese-enhanced magnetic resonance imaging of the rostral ventrolateral medulla of conscious rats: Importance of normalization and comparison with other regions of interest.NMR in biomedicine · 2018Article
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Article
- Identification of changes in neuronal function as a consequence of aging and tauopathic neurodegeneration using a novel and sensitive magnetic resonance imaging approach.Neurobiology of aging · 2017Article
- Blast-Induced Tinnitus and Elevated Central Auditory and Limbic Activity in Rats: A Manganese-Enhanced MRI and Behavioral Study.Scientific reports · 2017Article
- MRI of rod cell compartment-specific function in disease and treatment in vivo.Progress in retinal and eye research · 2016Review
- Preclinical Magnetic Resonance Imaging and Spectroscopy Studies of Memory, Aging, and Cognitive Decline.Frontiers in aging neuroscience · 2016Review
- Cocaine-induced locomotor sensitization in rats correlates with nucleus accumbens activity on manganese-enhanced MRI.NMR in biomedicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
In this study, we noninvasively tested the hypothesis that Mn(2+)-enhanced magnetic resonance imaging (MEMRI) is sensitive to age-related changes in Ca(2+) influx occurring in the hippocampal region CA1. Uptake of Mn(2+), an MRI contrast agent and Ca(2+) surrogate with low cellular efflux rates (days to weeks), was measured in longitudinal MEMRI studies involving 2 separate groups of male Long-Evans rats: one group was studied at 2.5 and 7 months of age, whereas the other was studied at 7 and 19 months of age. Separate or combined analysis revealed that the extent of Mn(2+) accumulation in CA1 significantly increased with age (p < 0.05). These results provide first-time in vivo confirmation of the calcium hypothesis of aging and justify future longitudinal studies combining MEMRI with behavioral testing to investigate mechanisms of age-related cognitive decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.